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High-resolution Cherenkov tomography in vivo

Nature Biomedical Engineeringvolume 2pages205206 (2018) | Download Citation

Shaping an X-ray beam as a thin sheet generates Cherenkov emissions that enable molecular sensing at submillimetre resolution and deep into tissue in small animals.

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References

  1. 1.

    Bolotovskii, B. M. Phys. Usp. 52, 1099–1110 (2009).

  2. 2.

    Cerenkov, P. A. C. R. Dokl. Akad. Nauk SSSR 2, 451–454 (1934).

  3. 3.

    Liu, H. et al. Small 6, 1087–1091 (2010).

  4. 4.

    Robertson, R. et al. Phys. Med. Biol. 54, N355–N365 (2009).

  5. 5.

    Ruggiero, A., Holland, J. P., Lewis, J. S. & Grimm, J. J. Nucl. Med. 51, 1123–1130 (2010).

  6. 6.

    Thorek, D. L., Ogirala, A., Beattie, B. J. & Grimm, J. Nat. Med. 19, 1345–1350 (2013).

  7. 7.

    Axelsson, J., Davis, S. C., Gladstone, D. J. & Pogue, B. W. Med. Phys. 38, 4127–4132 (2011).

  8. 8.

    Glaser, A. K., Zhang, R., Davis, S. C., Gladstone, D. J. & Pogue, B. W. Opt. Lett. 37, 1193–1195 (2012).

  9. 9.

    Shaffer, T., Drain, C. M. & Grimm, J. J. Nucl. Med. 57, 1661–1666 (2016).

  10. 10.

    Shaffer, T. M., Pratt, E. C. & Grimm, J. Nat. Nanotech. 12, 106–117 (2017).

  11. 11.

    Pogue, B. W. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0220-3 (2018).

  12. 12.

    Glaser, A. K. et al. Nat. Biomed. Eng. 1, 0084 (2017).

  13. 13.

    Thorek, D. L., Riedl, C. C. & Grimm, J. J. Nucl. Med. 55, 95–98 (2014).

  14. 14.

    Spinelli, A. E. et al. J. Biomed. Opt. 18, 20502 (2013).

  15. 15.

    Jarvis, L. A. et al. Int. J. Radiat. Oncol. Biol. Phys. 89, 615–622 (2014).

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Author information

Affiliations

  1. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    • Jan Grimm
  2. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    • Jan Grimm
  3. Pharmacology Program, Weill Cornell Medical College, New York, NY, USA

    • Jan Grimm
  4. Department of Radiology, Weill Cornell Medical College, New York, NY, USA

    • Jan Grimm

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Correspondence to Jan Grimm.

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DOI

https://doi.org/10.1038/s41551-018-0225-y

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