Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DIAGNOSTIC IMAGING

High-resolution Cherenkov tomography in vivo

Shaping an X-ray beam as a thin sheet generates Cherenkov emissions that enable molecular sensing at submillimetre resolution and deep into tissue in small animals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Generation of Cherenkov light.
Fig. 2: Comparison of CELSI and light-sheet microscopy.

References

  1. Bolotovskii, B. M. Phys. Usp. 52, 1099–1110 (2009).

    Article  CAS  Google Scholar 

  2. Cerenkov, P. A. C. R. Dokl. Akad. Nauk SSSR 2, 451–454 (1934).

    Google Scholar 

  3. Liu, H. et al. Small 6, 1087–1091 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Robertson, R. et al. Phys. Med. Biol. 54, N355–N365 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ruggiero, A., Holland, J. P., Lewis, J. S. & Grimm, J. J. Nucl. Med. 51, 1123–1130 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Thorek, D. L., Ogirala, A., Beattie, B. J. & Grimm, J. Nat. Med. 19, 1345–1350 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Axelsson, J., Davis, S. C., Gladstone, D. J. & Pogue, B. W. Med. Phys. 38, 4127–4132 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Glaser, A. K., Zhang, R., Davis, S. C., Gladstone, D. J. & Pogue, B. W. Opt. Lett. 37, 1193–1195 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shaffer, T., Drain, C. M. & Grimm, J. J. Nucl. Med. 57, 1661–1666 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Shaffer, T. M., Pratt, E. C. & Grimm, J. Nat. Nanotech. 12, 106–117 (2017).

    Article  CAS  Google Scholar 

  11. Pogue, B. W. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0220-3 (2018).

  12. Glaser, A. K. et al. Nat. Biomed. Eng. 1, 0084 (2017).

    Article  Google Scholar 

  13. Thorek, D. L., Riedl, C. C. & Grimm, J. J. Nucl. Med. 55, 95–98 (2014).

    Article  CAS  PubMed  Google Scholar 

  14. Spinelli, A. E. et al. J. Biomed. Opt. 18, 20502 (2013).

    Article  PubMed  Google Scholar 

  15. Jarvis, L. A. et al. Int. J. Radiat. Oncol. Biol. Phys. 89, 615–622 (2014).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jan Grimm.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grimm, J. High-resolution Cherenkov tomography in vivo. Nat Biomed Eng 2, 205–206 (2018). https://doi.org/10.1038/s41551-018-0225-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0225-y

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing