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Sustained miRNA release regenerates the heart

Prolonged local delivery, via an injectable hydrogel, of a miRNA known to induce cardiomyocyte proliferation stimulates the recovery of mice from myocardial infarction.

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  1. Gerbin, K.  A. & Murry, C.  E. Cardiovasc. Pathol.24, 133–140 (2015).

    Article  Google Scholar 

  2. Xin, M., Olson, E.  N. & Bassel-Duby, R. Nat. Rev. Mol. Cell Biol.14, 529–541 (2013).

    Article  CAS  Google Scholar 

  3. Pascual-Gil, S., Garbayo, E., Díaz-Herráez, P., Prosper, F. & Blanco-Prieto, M.  J. J. Control. Release203, 23–38 (2015).

    Article  CAS  Google Scholar 

  4. Taylor, D.  A., Sampaio, L.  C. & Gobin, A. Am. J. Transplant.14, 2448–2459 (2014).

    Article  CAS  Google Scholar 

  5. Wang, L. L. et al. Nat. Biomed. Eng. (2017).

    Article  CAS  Google Scholar 

  6. Tian, Y. et al. Sci. Transl. Med.7, 279ra238 (2015).

    Article  Google Scholar 

  7. Rodell, C.  B. et al. Adv. Funct. Mater.25, 636–644 (2015).

    Article  CAS  Google Scholar 

  8. Rodell, C.  B., Kaminski, A.  L. & Burdick, J.  A. Biomacromolecules14, 4125–4134 (2013).

    Article  CAS  Google Scholar 

  9. Rodell, C.  B. et al. Circ. Cardiovasc. Interv.9, e004058 (2016).

    Article  CAS  Google Scholar 

  10. Wang, L.  L. & Burdick, J.  A. Adv. Healthcare Mater.6, 1601041 (2017).

    Article  Google Scholar 

  11. van de Manakker, F., van der Pot, M., Vermonden, T., van Nostrum, C.  F. & Hennink, W.  E. Macromolecules41, 1766–1773 (2008).

    Article  Google Scholar 

  12. López, C.  A., de Vries, A.  H. & Marrink, S.  J. PLoS Comput. Biol.7, e1002020 (2011).

    Article  Google Scholar 

  13. Burdick, J.  A. & Prestwich, G.  D. Adv. Mater.23, H41–H56 (2011).

    Article  CAS  Google Scholar 

  14. Rupaimoole, R. & Slack, F.  J. Nat. Rev. Drug Discov.16, 203–222 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Charles E. Murry.

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C.E.M. is a scientific founder of BEAT Biotherapeutics and holds equity in the company.

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Mitzelfelt, K.A., Murry, C.E. Sustained miRNA release regenerates the heart. Nat Biomed Eng 1, 931–933 (2017).

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