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GENOME ENGINEERING

Repacking chromatin for therapy

Nature Biomedical Engineering volume 1, pages 858–859 (2017)Cite this article

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A theoretical model of chromatin packing heterogeneity predicts patterns in gene expression and can be used to screen for effective chemotherapeutic adjuvants.

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Fig. 1: Dynamic reorganization of the genome.

References

  1. Collins, F. S. N. Engl. J. Med. 341, 28–37 (1999).

    Article  CAS  PubMed  Google Scholar 

  2. Bailey, J. N. et al. Genes 5, 518–535 (2014).

    Article  PubMed  Google Scholar 

  3. Portella, A. & Esteller, M. Nat. Biotechnol. 28, 1057–1067 (2010).

    Article  Google Scholar 

  4. Almassalha, L. M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0153-2 (2017).

  5. De Gennes, P.-G. Scaling Concepts in Polymer Physics (Cornell University Press, Ithaca, NY, 1991).

  6. Halverson, J. D. et al. Rep. Prog. Phys. 77, 022601 (2014).

    Article  PubMed  Google Scholar 

  7. Cavalli, G. & Misteli, T. Nat. Struct. Mol. Biol. 20, 290–299 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Nagano, T. et al. Nature 502, 59–64 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Kumaran, R. I., Thakar, R. & Spector, D. L. Cell 21, 929–934 (2008).

    Article  Google Scholar 

  11. Hübner, M. R. & Spector, D. L. Annu. Rev. Biophys. 39, 471–489 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Chen, B. et al. Cell 155, 1479–1491 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Anton, T. et al. Nucleus 5, 163–172 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zidovska, A. et al. Proc. Natl Acad. Sci. USA 110, 15555–15560 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Bruinsma, R. et al. Biophys. J. 106, 1871–1881 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Soft Matter Research, Department of Physics, New York University, New York, NY, USA

    Alexandra Zidovska

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  1. Alexandra Zidovska
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Correspondence to Alexandra Zidovska.

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Zidovska, A. Repacking chromatin for therapy. Nat Biomed Eng 1, 858–859 (2017). https://doi.org/10.1038/s41551-017-0161-2

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