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Seeing whole-tumour heterogeneity

Nature Biomedical Engineeringvolume 1pages772774 (2017) | Download Citation

Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

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References

  1. 1.

    Baslan, T. & Hicks, J. Nat. Rev. Cancer 17, 557–569 (2017).

  2. 2.

    Tuchin, V. V. & Tuchin, V. Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis Vol. 642 (SPIE, Bellingham, 2007).

  3. 3.

    Renier, N. et al. Cell 159, 896–910 (2014).

  4. 4.

    Susaki, E. A. et al. Cell 157, 726–739 (2014).

  5. 5.

    Yang, B. et al. Cell 158, 945–958 (2014).

  6. 6.

    Ertürk, A. et al. Nat. Med. 18, 166–171 (2011).

  7. 7.

    Chung, K. et al. Nature 497, 332–337 (2013).

  8. 8.

    Kubota, S. I. et al. Cell Rep. 20, 236–250 (2017).

  9. 9.

    Pan, C. et al. Nat. Methods 13, 859–867 (2016). 

  10. 10.

    Tanaka, N. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0139-0 (2017).

  11. 11.

    Dobosz, M. et al. Neoplasia 16, 1–13 (2014).

  12. 12.

    Ertürk, A. et al. Nat. Protoc. 7, 1983–1995 (2012).

  13. 13.

    Shibue, T. & Weinberg, R. A. Nat. Rev. Clin. Oncol. https://doi.org/10.1038/nrclinonc.2017.44 (2017).

  14. 14.

    Nojima, S. et al. Sci. Rep. 7, 9269 (2017).

  15. 15.

    van Royen, M. E. et al. Histopathology 69, 985–992 (2016).

Download references

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Affiliations

  1. Department of Microvascular Biology and Pathobiology, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13–17, 68167, Mannheim, Germany

    • Boyan K. Garvalov
  2. Institute of Neuropathology, University of Giessen, Aulweg 128, 35392, Giessen, Germany

    • Boyan K. Garvalov
  3. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich, Feodor-Lynen str. 17, 81377, Munich, Germany

    • Ali Ertürk
  4. Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen str. 17, 81377, Munich, Germany

    • Ali Ertürk

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Corresponding authors

Correspondence to Boyan K. Garvalov or Ali Ertürk.

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https://doi.org/10.1038/s41551-017-0150-5

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