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Bioassays: Universal sensitivity booster

A universal ‘add-on’ method based on the ultrafast and localized deposition of polydopamine amplifies the sensitivity of a variety of bioassays for clinical diagnostics.

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Figure 1: Signal amplification by in situ reporter sequestration.
Figure 2: The EASE technology enables the visualization of Zika viral particles (red dots, left; arrows point to infected cells) in placental samples, whereas conventional immunofluorescence lacks sufficient sensitivity (right).

References

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Correspondence to Shana O. Kelley.

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Competing interests

S.O.K. has filed patents on diagnostic technologies and is a shareholder of Xagenic Inc., a company developing clinical diagnostics.

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Kelley, S. Bioassays: Universal sensitivity booster. Nat Biomed Eng 1, 0088 (2017). https://doi.org/10.1038/s41551-017-0088

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