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Implanted biomaterials: Neutrophil-mediated vascularization

The recruitment of neutrophils is indispensable for the formation of functional blood vessels in bioengineered grafts.

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Figure 1: Neutrophils mediate blood-vessel assembly and perfusion.
Figure 2: Neutrophils recruited to sprouting vascular endothelium in vitro and in vivo.

References

  1. Novosel, E. C., Kleinhans, C. & Kluger, P. J. Adv. Drug Delivery Rev. 63, 300–311 (2011).

    Article  CAS  Google Scholar 

  2. Rouwkema, J. et al. Trends Biotechnol. 26, 434–441 (2008).

    Article  CAS  Google Scholar 

  3. Lin, R.-Z. et al. Nat. Biomed. Eng. 1, 0081 (2017).

    Article  Google Scholar 

  4. Christoffersson, G. et al. Diabetes 59, 2569–2578 (2010).

    Article  CAS  Google Scholar 

  5. Phillipson, M. & Kubes, P. Nat. Med. 17, 1381–1390 (2011).

    Article  CAS  Google Scholar 

  6. Christoffersson, G. et al. J. Leukoc. Biol. (in the press).

  7. Fridlender, Z. G. et al. Cancer Cell 16, 183–194 (2009).

    Article  CAS  Google Scholar 

  8. Sylvestre-Roig, C., Hidalgo, A. & Soehlein, O. Blood 127, 2173–2181 (2016).

    Article  Google Scholar 

  9. Seignez, C. & Phillipson, M. Curr. Opin. Hematol. 23, 1–6 (2016).

    Article  Google Scholar 

  10. Christoffersson, G. et al. Blood 120, 4653–4662 (2012).

    Article  CAS  Google Scholar 

  11. Massena, S. et al. Blood 126, 2016–2026 (2015).

    Article  CAS  Google Scholar 

  12. Murdoch, C. et al. Nat. Rev. Cancer 8, 618–631 (2008).

    Article  CAS  Google Scholar 

  13. De Palma, M. et al. Cancer Cell 8, 211–226 (2005).

    Article  CAS  Google Scholar 

  14. Actin, A. et al. Nat. Immunol. 36, 240–249 (2104).

    Google Scholar 

  15. Fantin, A. et al. Blood 116, 829–840 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Mia Phillipson.

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Seignez, C., Phillipson, M. Implanted biomaterials: Neutrophil-mediated vascularization. Nat Biomed Eng 1, 0086 (2017). https://doi.org/10.1038/s41551-017-0086

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