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Optical diagnostics: Nanosensors for liquid biopsies

Nature Biomedical Engineering volume 1, Article number: 0063 (2017) Cite this article

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Carbon nanotubes enable the optical detection of nucleic acids in biofluids.

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Figure 1: Workflows for current miRNA-detection technologies.
Figure 2: Mechanism of detection of the SWCNT–DNA sensor.

References

  1. Bianchi, D. W. et al. N. Engl. J. Med. 370, 799–808 (2014).

    Article  CAS  Google Scholar 

  2. Kamhieh-Milz, J. et al. Biomed. Res. Int. 2014, 402475 (2014).

    Article  Google Scholar 

  3. Wan, J. C. et al. Nat. Rev. Cancer 17, 223–238 (2017).

    Article  CAS  Google Scholar 

  4. Hunt, E. A., Broyles, D., Head, T. & Deo, S. K. Annu. Rev. Anal. Chem. 8, 217–237 (2015).

    Article  CAS  Google Scholar 

  5. Leon, S. A., Shapiro, B., Sklaroff, D. M. & Yaros, M. J. Cancer Res. 37, 646–650 (1977).

    CAS  PubMed  Google Scholar 

  6. Calin, G. A. et al. N. Engl. J. Med. 353, 1793–1801 (2005).

    Article  CAS  Google Scholar 

  7. Harvey, J. D. et al. Nat. Biomed. Eng. 1, 0041 (2017).

    Article  Google Scholar 

  8. Guo, Y. et al. BMC Genomics 18, 50 (2016).

    Article  Google Scholar 

  9. Witwer, K. W. Clin. Chem. 61, 56–63 (2015).

    Article  CAS  Google Scholar 

  10. Bustin, S. A. et al. Clin. Chem. 55, 611–622 (2009).

    Article  CAS  Google Scholar 

  11. Etheridge, A., Gomes, C. P., Pereira, R. W., Galas, D. & Wang, K. Front. Genet. 4, 115 (2013).

    Article  CAS  Google Scholar 

  12. Zhou, Q. et al. Anal. Chem. 88, 4759–4765 (2016).

    Article  CAS  Google Scholar 

  13. Huang, X., O’Connor, R. & Kwizera, E. A. Nanotheranostics (Syd) 1, 80–102 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Irene de Lázaro and Kostas Kostarelos are at the Nanomedicine Lab, Faculty of Biology, Medicine & Health and at the National Graphene Institute, University of Manchester, AV Hill Building, Manchester M13 9PT, UK.,

    Irene de Lázaro & Kostas Kostarelos

Authors
  1. Irene de Lázaro
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  2. Kostas Kostarelos
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Correspondence to Kostas Kostarelos.

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de Lázaro, I., Kostarelos, K. Optical diagnostics: Nanosensors for liquid biopsies. Nat Biomed Eng 1, 0063 (2017). https://doi.org/10.1038/s41551-017-0063

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