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Cancer immunotherapy: Wound-bound checkpoint blockade

Nature Biomedical Engineering volume 1, Article number: 0031 (2017) | Download Citation

Platelets delivering the immunotherapeutic antibody anti-PD-L1 to the site of surgically removed tumours reduce cancer recurrence and metastatic spread in mice.

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References

  1. 1.

    , & Science 271, 1734–1736 (1996).

  2. 2.

    et al. J. Exp. Med. 192, 1027–1034 (2000).

  3. 3.

    et al. Nat. Rev. Clin. Oncol. 13, 473–486 (2016).

  4. 4.

    et al. J. Clin. Oncol. 33, 1889–1894 (2015).

  5. 5.

    Nat. Rev. Drug. Discov. 13, 883–884 (2014).

  6. 6.

    et al. Ann. Oncol. 27, LBA41_PR (2016).

  7. 7.

    et al. N. Engl. J. Med. 375, 1845–1855 (2016).

  8. 8.

    , & Head Neck 27, 952–958 (2005).

  9. 9.

    et al. Nat. Biomed. Eng. 1, 0011 (2017).

  10. 10.

  11. 11.

    , & Blood 126, 582–588 (2015).

  12. 12.

    & Science 348, 56–61 (2015).

  13. 13.

    et al. Lancet Oncol. 16, 375–384 (2015).

  14. 14.

    , , & Nat. Rev. Cancer 17, 20–37 (2017).

  15. 15.

    et al. Nature 526, 118–121 (2015).

Download references

Author information

Affiliations

  1. Morteza Mahmoudi and Omid C. Farokhzad are at the Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

    • Morteza Mahmoudi
    •  & Omid C. Farokhzad

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Corresponding authors

Correspondence to Morteza Mahmoudi or Omid C. Farokhzad.

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DOI

https://doi.org/10.1038/s41551-017-0031

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