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Drug delivery: Brushing off antigenicity

Conjugation of a diabetes drug with a brush polymer reduces the reactivity of the drug conjugate towards pre-existing polymer antibodies in human plasma and improves the drug's performance in diabetic mice.

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Figure 1: A PEGylation approach for improving drug half-life and eliminating PEG antigenicity.


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Correspondence to Kang Choon Lee or Seulki Lee.

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Lee, K., Lee, S. Drug delivery: Brushing off antigenicity. Nat Biomed Eng 1, 0019 (2017).

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