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Image-guided surgery: Transistor-like pH nanoprobes

Nanoprobes that fluoresce only when activated by the acidic environment in tumours may make a universal imaging agent for cancer surgery.

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Figure 1: Optimal pre-clinical assessment of fluorescence agents for tumour imaging.
Figure 2: Radioisotope imaging (FDG–PET), and intraoperative imaging with white light and pH-sensitive, near-infrared fluorescent nanoprobes in severe-combined-immunodeficiency mice bearing large (top row) and small (bottom row) head-and-neck tumours.


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Correspondence to Eben L. Rosenthal.

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van den Berg, N., Rosenthal, E. Image-guided surgery: Transistor-like pH nanoprobes. Nat Biomed Eng 1, 0018 (2017).

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