Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Tumour mechanopathology: Cutting the stress out

Solid stress within tumours can be quantified by measuring their deformation after cutting, slicing or taking a needle biopsy of them.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Three methods for measuring solid stress in ex vivo tumours.

References

  1. 1

    Wirtz, D., Konstantopoulos, K. & Searson, P. C. Nat. Rev. Cancer 11, 512–522 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Goetz, J. G. et al. Cell 146, 148–163 (2011).

    CAS  Article  Google Scholar 

  3. 3

    Lopez, J. I., Mouw, J. K. & Weaver, V. M. Oncogene 27, 6981–6993 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Gilkes, D. M., Semenza, G. L. & Wirtz, D. Nat. Rev. Cancer 14, 430–439 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Paszek, M. J. et al. Cancer Cell 8, 241–254 (2005).

    CAS  Article  Google Scholar 

  6. 6

    Provenzano, P. P., Inman, D. R., Eliceiri, K. W. & Keely, P. J. Oncogene 28, 4326–4343 (2009).

    CAS  Article  Google Scholar 

  7. 7

    Helmlinger, G., Netti, P. A., Lichtenbeld, H. C., Melder, R. J. & Jain, R. K. Nat. Biotechnol. 15, 778–783 (1997).

    CAS  Article  Google Scholar 

  8. 8

    Stylianopoulos, T. et al. Proc. Natl Acad. Sci. USA 109, 15101–15108 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Ou, G. & Weaver, V. M. Bioessays 37, 1293–1297 (2015).

    CAS  Article  Google Scholar 

  10. 10

    Nia, H. T. et al. Nat. Biomed. Eng. 1, 0004 (2016).

  11. 11

    Conklin, M. W. et al. Am. J. Pathol. 178, 1221–1232 (2011).

    Article  Google Scholar 

  12. 12

    Lu, P., Weaver, V. M. & Werb, Z. J. Cell Biol. 196, 395–406 (2012).

    CAS  Article  Google Scholar 

  13. 13

    Choi, W. J. et al. Ultrasound Med. Biol. 40, 269–274 (2014).

    Article  Google Scholar 

  14. 14

    Kumar, V. et al. Transl. Oncol. 9, 431–437 (2016).

    Article  Google Scholar 

  15. 15

    Provenzano, P. P. et al. Cancer Cell 21, 418–429 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Denis Wirtz.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gilkes, D., Wirtz, D. Tumour mechanopathology: Cutting the stress out. Nat Biomed Eng 1, 0012 (2017). https://doi.org/10.1038/s41551-016-0012

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing