Table 3 Binding of secreted forms of RSV F protein to conformation-indicating antibodies following transfection of modified mRNAs into Expi293F cells.

From: Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

  D25 binding (ng/mL) 4D7 binding (ng/mL) AM14 binding (ng/mL)
sF 0.0 28.3 0.0
sDS-Cav1 30.0 2.8 25.7
RSV F5 1.8 2.0 0.0
RSV F8 14.7 30.0 0.0
No mRNA 0.0 0.0 0.0