Fig. 4 | npj Vaccines

Fig. 4

From: Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis

Fig. 4

Ty21a-PA-01 protects rabbits from a high dose lethal Ames spore challenge. Rabbits were immunized with 1 × 109 CFU of Ty21a control (filled triangles) or Ty21a-PA-01 (open squares) by the IP route four times at 4-week intervals. Two weeks after dose 4, rabbits were challenged with aerosolized Ames spores at a dose of 200 LD50 and monitored twice daily for 21 days. Mean TTD was calculated. None of ten control rabbits immunized with Ty21a survived; however, 7/10 rabbits immunized with Ty21a-PA-01 survived (p = 0.0031, Fisher’s exact test, two-tailed). All 10 control rabbits died in 1.8 ± 0.4 days, and the mean TTD for the 3 immunized rabbits that died was 3.2 ± 1 days (p = 0.039by Mann–Whitney U test, two-tailed)

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