Fig. 3 | npj Systems Biology and Applications

Fig. 3

From: Integrating personalized gene expression profiles into predictive disease-associated gene pools

Fig. 3

Functional characteristics of the genes in PEEPs. a A schematic figure illustrating how the same pathway associated with a specific function may be disrupted by perturbations at different locations in different subjects. b Individual perturbations of all asthmatic subjects within the asthma-specific pathway IFN-γ and Th2 cytokines-induced inflammatory signaling in normal and asthmatic airway epithelium. Each row corresponds to one pathway gene and each column to one subject. On the right: the number of subjects that have the respective gene up-regulated or down-regulated. Below: number of up-regulated or down-regulated genes within the pathway for each subject. c Pairwise similarity as measured by the Jaccard index of the pathway perturbations of all subject pairs whose profiles are significantly enriched within the pathway (Fisher’s exact test with Bonferroni correction, p-value <0.05) for all considered asthma-specific pathways (see Supplementary Table 1). Note that only the genes within the respective pathway areused for the comparison. d-f as in (c), but averaged over all geneGO terms and general MSigDB pathways that are significantly enriched in the profiles of the respective subjects (see Methods). BP biological process, MF molecular function, CC cellular component

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