Fig. 4 | npj Regenerative Medicine

Fig. 4

From: Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context

Fig. 4

Transcriptomic profiling of vegfchy−/−;vegfd−/− mutant hearts reveals a disruption in cell proliferation and lipid metabolism. a Unsupervised hierarchical clustering showing distinct transcriptional profiles for vegfc+/+:vegfd+/+ control ventricles and in vegfchy−/−:vegfd−/− mutant ventricles. b Volcano plot of vegfc+/+:vegfd+/+ control ventricles and vegfchy−/−:vegfd−/− mutant ventricles. The top 10 upregulated genes for each comparison are indicated. Genes highlighted in red have a FDR < 0.05. Gene set enrichment analysis (GSEA) of vegfc+/+:vegfd+/+ control (c) and vegfchy−/−;vegfd−/− mutant ventricles (d). Representative pathways are highlighted with circles and gene set sizes are represented by circle sizes. GSEA indicates that the vegfchy−/−;vegfd−/− mutant ventricles are characterized by an upregulation of pathways related to cell proliferation and lipid metabolism compared with vegfc+/+:vegfd+/+ control hearts

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