Fig. 3 | npj Regenerative Medicine

Fig. 3

From: Combination of stem cell and gene therapy ameliorates symptoms in Huntington’s disease mice

Fig. 3

Immunohistochemistry reveals the differentiation of NPC grafts in mouse brains. The top panels show mouse brains with WT-NPCs grafts. The middle panels show mouse brains grafted with HD-NPCs. The bottom panels show mouse brains grafted with HD-shHD-NPCs. Wild-type mouse brains are shown on the left, and the HD mouse brains are shown on the right. More WT-NPCs survived, distributed, and differentiated into neural cells than compared to both HD-NPC and HD-shHD-NPCs. All three cell lines were able to differentiate into MAP2, GFAP, and GABA positive cells in vivo. All pictures were taken at 40×. The scale bar represents 50 µm

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