Fig. 2 | npj Regenerative Medicine

Fig. 2

From: Combination of stem cell and gene therapy ameliorates symptoms in Huntington’s disease mice

Fig. 2

Longitudinal behavior assessments of HD mice grafted with NPCs. a Linear regression analysis of the rotarod data showed significant improvement in rotarod performance of the HD mice receiving WT-NPC (green) (P = 0.0468) and HD-shHD-NPC (blue) (P = 0.0026) compared to sham injection group (black). b Linear regression analysis of the grip strength data showed significant improvement of the grip strength in HD mice receiving WT-NPC (green) (P = 0.0014) and HD-shHD-NPC (blue) (P = 0.0077) compared to sham injection group (black). No statistical significance was found between HD-NPC and sham injection group (P = 0.7103). c Kaplan–Meier graph of HD mice grafted with NPCs. A significant increase in lifespan was observed when HD-shHD-NPC group was compared to the sham injection group (\(\tilde x = 24.0\) weeks and \(\tilde x = 19.0\) weeks) (P = 0.02). d Linear regression analysis of the weight did not show significant difference among the groups. HD/NT (n = 7), HD/Sham (n = 5), HD/WT-NPC (n = 5), HD/HD-NPC (n = 5), and HD/shHD-NPC (n = 5)

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