Fig. 6: | npj Regenerative Medicine

Fig. 6

From: Sustained release of decorin to the surface of the eye enables scarless corneal regeneration

Fig. 6

Mechanisms of corneal fibrosis and the effects of hrDecorin fluid gel. If corneal wound-healing fails, high concentrations of TGFβ result in the continued activation of myofibroblasts within the stroma leading to excessive ECM deposition, disorganized collagen, and inflammation resulting in corneal fibrosis. At this point, although endogenous decorin is present, it is unable to maintain corneal homeostasis. This may be due to insufficient concentrations to inhibit TGFβ hyperactivity or because the endogenous decorin is not freely available and bound within the ECM. Providing a sustained release of exogenous hrDecorin from the fluid gel helps to increase decorin levels and reduce TGFβ hyperactivity, thus providing a permissive environment for wound healing, corneal remodeling, and restoration of corneal integrity