Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson’s disease


Levodopa-carbidopa intestinal gel (LCIG) has shown to be efficacious in motor and non-motor symptoms (NMS). Nevertheless, studies with patient Quality of Life (QoL) as a primary endpoint are scarce. To assess the effect of LCIG on Advanced Parkinson’s Disease (APD) patients QoL. Secondarily, the impact on motor symptoms and NMS, emotional well-being, treatment satisfaction, and caregiver QoL, stress, disease burden, anxiety, depression, and work impairment were also investigated. In this prospective, 6-month multicenter postmarketing observational study, LCIG was administered to 59 patients with APD. Endpoints were assessed using validated scales and questionnaires. LCIG significantly improved patient QoL (PDQ-39 mean change ± standard deviation from baseline, −12.8 ± 14.6; P < 0.0001), motor symptoms (UPDRS-III in “On,” −6.5 ± 11.8; P = 0.0002), NMS (NMSS, −35.7 ± 31.1; P < 0.0001), mood (Norris/Bond-Lader VAS, −6.6 ± 21.1; P = 0.0297), fatigue (PFS-16, −0.6 ± 1.0; P = 0.0003), depression (BDI-II, −5.1 ± 9.4; P = 0.0002), anxiety (BAI, −6.2 ± 9.6; P < 0.0001), and patient treatment satisfaction (SATMED-Q, 16.1 ± 16.8; P < 0.0001). There were significant correlations between the change from baseline to 6 months between PDQ-39 and UPDRS-IV, NMSS, BAI, BDI-II, AS, and PFS-16 scores, and Norris/Bond-Lader alertness/sedation factor. Caregiver anxiety also improved (Goldberg anxiety scale, −1.1 ± 1.0; P = 0.0234), but the clinical relevance of this finding is questionable. The serious adverse events reported were similar to those previously described for LCIG. In patients with APD, LCIG improves QoL, motor symptoms and NMS, emotional well-being, and satisfaction with the treatment. Improvement in patient QoL is associated with improvements in motor complications, NMS, anxiety, depression, apathy and fatigue. Improvements in patients’ QoL does not correspond with improvements in caregivers’ QoL or burden.


Parkinson disease (PD) is characterized not only by the presence of “classical” motor symptomatology, but also by multiple non-motor symptoms (NMS) of different nature, which cause disability and impact quality of life (QoL), especially in the advanced stage of the disease1. At this stage, when oral medication no longer controls motor fluctuations but patients still respond to levodopa, three device-aided therapies (DATs) may be considered: deep brain stimulation (DBS), levodopa-carbidopa intestinal gel (LCIG) or apomorphine injection and infusion. LCIG and DBS have shown to improve patient’s QoL in clinical trials2,3, but no apomorphine that failed to show this effect in a placebo-controlled study4. LCIG is a valid option for most patients who are considered for DBS and for many of the patients for whom DBS is contraindicated. However, all 3 DATs have demonstrated significant improvements in motor fluctuations2,3,4. So, in the absence of randomized controlled clinical trials among them, the best available evidence (efficacy, contraindications and possible adverse reactions) should be combined with the professional’s expertise and the patient’s preferences to make a decision.

Health-related QoL is a patient-reported outcome considered to be a key measure of patient global status1, and should be the main purpose of any PD symptomatic treatment. Disease-specific instruments, such as the 39-item Parkinson’s Disease Questionnaire (PDQ-39)5, are valuable in assessing disease-specific problems and measuring the success of treatment in altering QoL over time6. The PDQ-39 has been shown to be feasible, reliable, valid, and responsive to change in patients with PD.

LCIG has demonstrated benefits controlling motor fluctuations and NMS in patients with advanced PD (APD) in randomized, controlled, clinical trials2,7 and observational studies8,9,10,11,12,13,14,15,16,17,18,19. QoL has been assessed in some of them2,8,10,11,12,13,14,15,16,17,18,19 as a secondary objective, showing significant improvements; however, data on the impact of LCIG on patient’s mood and behavior are scarce. In addition, in most of the studies the questionnaire used was the PDQ-88,10,12,14,15,17. PDQ-8 is a short form of the PDQ-39 and, although it has been validated, it has the disadvantage that it does not offer the possibility to assess individual domains but just a simplified index and, for this reason, PDQ-8 is more convenient for using in clinical settings rather than in clinical research.

We conducted this study to assess, the effect of 6-month treatment with LCIG on the QoL of patients with APD using the self-reported PDQ-39. Additionally, we assessed patient’s NMS related to emotional well-being and satisfaction with treatment, as well as caregiver QoL, burden, and other symptoms/aspects related with his/her role as caregivers of a patient with APD. We hypothesized that LCIG will significantly improve the patient’s QoL, and this improvement will correlate with the improvements in motor and non-motor symptoms, and patient’s emotional well-being, as well as in the caregiver QoL.


Baseline characteristics

Sixty-two patients and caregivers from 23 Spanish centers were enrolled; 59 were evaluable and constituted the intent-to-treat and safety populations. Three patients were non-evaluable because they did not reach the nasoduodenal test phase.

The mean age of patients was 67.9 ± 7.5 years and 61.0% were male; the mean age of caregivers was 58.8 ± 11.7 years and 64.4% were female. The clinical and sociodemographic characteristics of patients and caregivers are shown in Tables 1 and 2, respectively.

Table 1 Clinical and socio-demographic characteristics of the patients, at baseline.
Table 2 Baseline sociodemographic characteristics of caregivers and global scores of SQLC, ZBI, CSI, Goldberg Anxiety Scale, Goldberg Depression Scale, and WPAI.

Changes from baseline to last visit

The mean dose of LCIG administered to the patients increased from 75.52 ± 94.24 mL, at hospital discharge (after LCIG dose titration), to 84.45 ± 70.73 mL at the final visit, corresponding to 1510.33 ± 1,884.73 mg and 1689.00 ± 1,414.62 mg of levodopa, respectively. The mean LEDD increased from baseline (1099.04 ± 538.16 mg) to the final visit (1861.43 ± 1389.97 mg; P < 0.0002), the dopamine agonists LEDD gradually reduced from 225.18 ± 125.20 mg at baseline to 125.00 ± 77.01 mg at the final visit (P < 0.0001), and the rest of the antiparkinsonian drugs remain constant throughout the study.

Patients´ QoL, represented by the PDQ-39 Summary Index as a whole, significantly improved throughout the study (Figs. 1 and 2). Changes were also statistically significant in all PDQ-39 domains, except in the “social support” domain.

Fig. 1: PDQ-39, 39-item Parkinson’s Disease Questionnaire.
figure 1

A Summary index. B Domain scores. White bars: data at baseline, black bars: data at final visit. P values for PDQ-39 score comparison between final visit and baseline. Values are given as mean ± SD.

Fig. 2: PDQ-39 summary index evolution from baseline to final visit.
figure 2

Violin plots representing the frequency and box plots representing the interquartile range containing 50% of the data, the median and the 95% confidence interval.

Compared with baseline scores, motor symptoms (UPDRS III) and motor complications (UPDRS IV) were also significantly improved throughout the study visits. The mean daily hours of “Off” time were reduced from 5.78 ± 3.00 to 2.34 ± 2.84 at the final visit (P < 0.0001). The mean total daily “On” time with dyskinesia decreased from 4.6 ± 4.8 at baseline to 3.5 ± 4.0 at the final visit although this reduction didn’t reach the statistical significance level (P = 0.077). The mean UPDRS-IV score was reduced from 3.58 ± 1.97 to 1.47 ± 1.31 at the final visit (P < 0.0001). There were no statistical differences in activities of daily living (ADL) assessed using the S&E scale in the “On” state (from 70.3 ± 23.1 to 75.5 ± 18.2; P = 0.29). NMS improved after 6 months of treatment with LCIG. Changes in NMSS scores, both total score and all domain scores, were significantly improved from baseline to the final visit (difference, 35.75 ± 31.12, P < 0.0001; percentage relative change, 41.41 ± 34.22, P < 0.0001; Figs. 3 and 4). Sleep/fatigue and gastrointestinal domains were the most improved domains (percentage relative change, 51.51 ± 39.52 and 34.01 ± 62.90, respectively).

Fig. 3: NMSS, Nonmotor symptom scale.
figure 3

A Total score. B Domain scores. White bars: data at baseline, black bars: data at final visit. P-values for NMSS score comparison between final visit and baseline. Values are given as mean ± SD.

Fig. 4: NMSS total score evolution from baseline to final visit.
figure 4

Violin plots representing the frequency and box plots representing the interquartile range containing 50% of the data, the median and the 95% confidence interval.

At the end of the study, patients had a statistically significant positive change in mood. When the Norris/Bond-Lader factors were analyzed, there was a statistically significant improvement in alertness/sedation and calmness/relaxation, with mean scores changing from 44.8 ± 19.7 to 37.7 ± 17.3 (P = 0.028) and from 53.9 ± 23.2 to 45.2 ± 23.6 (P = 0.005), respectively. The improvement observed in the content/discontent factor (from 34.2 ± 18.5 to 30.9 ± 17.8) was not significant (P = 0.27). By contrast, no significant differences were observed in caregivers’ outcomes, except for anxiety.

Table 3 shows the mean changes observed in all primary and secondary endpoints. The comparisons of primary and secondary variables per visits (mixed model) were not statistically significant.

Table 3 Mean change ± SD from baseline to final visit (6 months ± 15 days) in the primary and secondary study endpoints (final score—baseline score).

At baseline, 27.1% of patients (16/59) were also receiving concomitant treatments for PD-related symptoms, including anxiety (n = 14), depression (n = 12), insomnia (n = 6), psychosis (n = 5), constipation (n = 5), or pain (n = 4). At the end of the study, half of these patients discontinued ≥1 concomitant treatment. In general, there was a reduction in all concomitant medications decreasing in a 19.0, 18.5, 16.7, 14.3, and 12.5 in anxiolytic, antidepressant, antipsychotic, insomnia, and constipation drug uses, respectively. No pain treatments were discontinued during the study.

Correlations related with Quality of Life improvements

Significant correlations were observed between improvement in patient QoL and improvements in motor complications, NMS, anxiety, depression, apathy, fatigue, and the Norris/Bond-Lader alertness/sedation factor. After consideration of multicollinearity of possible independent predictors, a multivariate regression analysis showed that the variables that had the highest contributions to the model were PFS-16, NMSS, and SQLC (adjusted R2 = 0.43, F = 9.41, P < 0.001) (Table 4).

Table 4 Multivariate analysis with PDQ-39 as dependent variable and the most relevant predictor variables as independent variables.

Safety data

Overall, 13 patients reported 18 SAEs. Three were reported in the nasoduodenal phase of study; of these SAEs, only 1 (pneumoperitoneum) was related to LCIG use. In the post-PEG phase, 15 SAEs were reported, seven were related to LCIG (ventricular tachycardia, gastrointestinal ulcer, paralytic ileus, pneumoperitoneum, infection, peripheral sensory neuropathy, and substance-induced psychotic disorder). Six (10.17%) out of the 59 patients prematurely discontinued the study, three during the nasoduodenal test phase (due to lack of efficacy in two cases, and due to a very narrow therapeutic margin in one case); and three after the PEG intervention phase (in one case due to lack of efficacy, due to exitus in other case, and due to patient’s decision in the third case). In addition, none of deaths were related to LCIG.


In our study, after 6 months of treatment with LCIG administered in daily clinical practice, the QoL of patients with APD improved significantly, which is consistent with results obtained in other interventional2,7 and observational8,9,10,11,12,13,14,15,16,17,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34 studies in which QoL was assessed as a secondary endpoint. There was a 28% reduction in PDQ-39 scores after 6 months of treatment, which is a relevant result; the conclusions of the Society for Medical Decision-Making states that patients appear to be able to detect and value benefits when changes are >7 to 10% on QoL instruments or pain scales35. In our study, there was a statistically significant improvement in all domains except social support, which is in line with results from previous studies. Interestingly, social support only improved significantly in the Zibetti et al. study; 7 of 17 participants in this study had probable dementia, and the improvement in the social support domain was prominent in this subgroup of patients33. The results of the studies of patients receiving LCIG treatment are similar to the results for other second-line therapies (SLTs) in PD. Results from the OPTIPUMP study, which was similar to the ADEQUA study in terms of population and design, for patients receiving continuous subcutaneous apomorphine infusion, noted a reduction in the total score of the PDQ-39, although half of the domains did not have statistically significant reductions (4 out of 8), with social support being one of them36. Recently, Dafsari et al. investigated whether results in QoL outcomes after bilateral subthalamic nucleus deep brain stimulation are dependent on age. In this study, an improvement in the social support domain of the PDQ-39 was only observed in the youngest subgroup of patients (≤59 years old)37.

When motor symptoms and motor complications were assessed in our study, a significant improvement was noted in UPDRS III and IV scores, as observed in other studies7,8,11,12,13,15,16,17,20,21,24,26,29,30,32,33,38. Similarly, regarding NMS, there was a statistically significant improvement in NMSS total score in our study that corresponds with the results of other studies, in which NMSS total score improved significantly8,10,11,12,13,14,15,16,34,38. We also saw a significant improvement in all NMSS domains. When compared with other studies, sleep/fatigue and gastrointestinal tract were the NMSS domains that most frequently showed a statistically significant improvement (seven out of nine)8,11,12,14,15,16,34. In our study, the greatest benefit from LCIG treatment was observed in the NMSS score, which could explain the relevant result we found in PDQ-39 score6.

Treatment with LCIG also had a positive impact in patient emotional well-being, with improvements in mood, fatigue, depression, and anxiety. There were no statistically significant effects in apathy after 6 months of treatment. This could be related to dopamine agonist withdrawal39. It has been showed that depression40,41,42,43,44, fatigue41,45,46,47,48, apathy45,49, anxiety42,50, and mood46,51,52 have an impact on QoL in patients with PD; thus, it is not surprising that the improvements in these symptoms observed in our study correspond with the improvement noted in patient QoL.

Thus, patients in this study generally improved in relation to all aspects of APD. However, there were no statistically significant improvements in ADL as measured using the S&E scale, although improvements of the ADL domain in the PDQ-39 were noted. The S&E scale has been used extensively in patients with PD in recent years. While the clinimetric properties of this scale have never been established53, the International Parkinson and Movement Disorder Society Task Force in 2016 recommended its use in PD, both for clinical and research purposes54. Although the inter-rater reliability between patient and physician ratings seems to be high54, in our study, the S&E scale was completed by the neurologist. It is possible, therefore, that the physician rating could differ from the patient rating, based on results observed in the ADL domain of the PDQ-39. It should be noted that the PDQ-39 requested information from the past month (“Off” and “On”), whereas the S&E scale was evaluated at baseline and the final visit in the “On” state.

Special attention should be given to the caregiver results. We did not find a statistically significant effect in caregiver QoL, which is in concordance with the results of Sensi et al.17, but in contradiction with the results of Ciurleo et al.19. Surprisingly, except for anxiety, there was no improvement in a single scale in caregiver status. The stress index and depression of caregivers were unaffected. This is somewhat striking, as patient’s depression has been found to be related to caregiver’s depression55. Regarding caregiver’s anxiety, despite the fact that the reduction observed in the Goldberg anxiety scale was statistically significant, clinical relevance might be minimal as the final total score (6.4) was still above the cut-off point for anxiety (≥4). In some studies, caregiver’s burden improved;19,24,31 in others, no improvement was noted2,11,18. In our study, the ZBI score was low at baseline; therefore, there was little margin for improvement. This may be related to the exclusion of patients with dementia, a factor that contributes negatively to caregiver burden56,57. Similarly, other studies have not observed improvements in caregiver’s burden in patients with APD treated with an SLT58. There was also no improvement in WPAI scores in caregivers due to patient disability. There could be a few hypotheses of why patients improved motor symptoms, NMS, emotional well-being, and QoL but caregivers seemed not to be benefit from it. First, it is possible that the sample size for caregivers was too small to provide the appropriate statistical power (specifically for the WPAI questionnaire, where the number of currently employed caregivers was only 16 [of 59 caregivers in the study]). Another possible explanation was that study period (6 months) was not long enough of a timeline for caregivers of chronic, disabled, and advanced patients to observe a change (a statistically significant effect has been found in prospective long-term studies24,31), when a strong relation of dependence, with certain resistance to change, has already been established between the patient and the caregiver. If this is the case, it should not be assumed that an improvement in the quality of life of patients with advanced Parkinson’s disease corresponds to an immediate improvement in the quality of life of their caregivers. Finally, LCIG is an invasive treatment and a device-aid therapy that requires care and learning, which could negatively impact the caregiver, mainly during the first months that follow the beginning of LCIG therapy. The fact that patients receiving LCIG infusions are more active from the motor point of view probably requires more intense caregiver attention. All these factors could cause difficulties for caregivers after the PEG procedure at home. We should not forget that, based on Santos-García et al. study59, the main factors contributing to burden and stress in caregivers are mood (BDI-II) and ADL, which improved in our study according to the PDQ-39, but remained unchanged in the S&E scale.

Improvements in patient QoL (PDQ-39) correlated with improvements in UPDRS-IV; NMSS total score; BAI, BDI-II, AS, and PFS scores; and the Norris/Bond-Lader alertness/sedation factor, though the correlations were not strong. Nevertheless, none of the improvements observed in patient variables correlated with any of the caregiver variables, which is in contrast with the results obtained by Santos-García et al., which found a correlation between PDQ-39 scores and caregiver burden (ZBI)31. In the post hoc multivariate analysis, the QoL questionnaire for caregivers (SQLC) was one of the main variables that showed greater relation to the improvement in patient QoL (PDQ-39)31.

This study provides important clinical data related to the use of LCIG and how treatment improves motor symptoms, NMS, and overall QoL in patients with APD. This study also showed improvement in fatigue, depression, and anxiety in non-selected patients with PD under routine care treated with LCIG, using validated questionnaires. One of the study’s strengths was the assessments on caregivers. There are also inherent limitations associated with this study’s design, namely that it was an observational non-controlled study. Firstly, the potential contribution of unknown/unmeasured confounding factors when the correlation between patient and caregiver QoL was assessed against the other variables. Secondly the potential contribution of a placebo effect overestimating response, particularly when subjective variables are analyzed. Thirdly, the QoL evaluation was assessed using a health-related QoL tool, which was not accompanied by a generic QoL tool, such as the EuroQoL-5 Dimensions questionnaire. And, finally, although per inclusion criteria all patients at baseline had to score at least 26 at the MMSE, an even mild cognitive decline might have affected the reported outcomes.

To end, the safety profile of LCIG described in this study and the rate of discontinuations are comparable to the data published previously in the literature2,8 and collected in the Summary of Product Characteristics. In our study, 13 out of 62 patients reported 18 SAEs, of those, only 8 SAEs were related with LCIG and of those 5 SAEs were related to the percutaneous endoscopic gastrostomy. To this regard, comparisons with other SLTs are difficult to make due to different studies methodologies and follow-up periods. However, we can find that most of the SAEs reported by patients treated with SLTs are related to the surgery or the device. Thus, in the study of Dafsari et al. in which 54 patients who underwent bilateral STN-DBS and were followed-up for an approximately 5 months after surgery, 5 patients reported SAEs related to surgery or device or to stimulation37. Regarding apomorphine pump, in the study of Drapier et al. 143 patients were enrolled, of them 42 patients withdrew from the study due to drug intolerance, lack of efficacy or other reasons. Out of 100 patients who finally completed the study and had available data at 6 months, 13 reported 17 SAEs, being the most common those affecting patients’ skin36.

In summary, 6-month treatment with LCIG administered in routine clinical practice improved the QoL of patients with APD, as well as motor symptoms and NMS, emotional well-being, and caregiver anxiety. Improvements in PDQ-39 were associated with improvements in UPDRS-IV, NMSS, BAI, BDI-I, AS, and PFS-16 scores, and the Norris/Bond-Lader alertness/sedation factor. However, patients’ QoL improvements do not correspond with improvements in caregivers’ burden or caregivers’ QoL. Further studies focused on the correlation between patients’ motor symptoms, non-motor symptoms, and QoL with burden and QoL of caregivers may be warranted.


ADEQUA was a multicenter, postmarketing, observational, prospective, 6-month single-arm study conducted with APD patients treated with LCIG, prescribed in routine clinical practice in accordance with the terms of the local marketing authorization, from October 2014 to November 2016 at 23 Spanish hospitals.

The study was conducted in accordance with the ethical principles that have their origin in the Declaration of Helsinki, with the protocol, and with standard operating procedures that guaranteed compliance with Good Clinical Practice, as described in the ICH guidelines. Following local regulations, the study was evaluated by the Spanish Agency of Medicines and Medical Devices and was approved by the Spanish Autonomous Communities and the ethics committees of the participating hospitals. All patients provided written informed consent before enrollment in the study.


Eligible participants were outpatients aged ≥18 years with advanced levodopa-responsive PD with a diagnosis of idiopathic PD according to the UK Parkinson’s Disease Society Brain Bank Diagnosis Criteria60, with at least 2 h of daily “Off” time or 2 h of daily dyskinesia (assessed following MDS UPDRS-IV instructions). All patients had no dementia criteria, and had a Mini-Mental State Examination score ≥26, following Movement Disorders Society taskforce on dementia in PD recommendations61. Patients were excluded if they had any LCIG’s contraindication included in the Summary of Product Characteristics or product label. Information about the principal caregiver was collected when possible. The principal caregiver was the person in charge of the patient’s care most of the daytime.

Efficacy assessments were collected at baseline before LCIG treatment initiation with temporary nasojejunal (concomitant PD medications were administered at the discretion of treating physician), at discharge from hospital following Percutaneous Endoscopy Gastrostomy (PEG) placement, and at months 1, 3, and 6.


The primary endpoint was the mean change in PDQ-3962 score from baseline (before LCIG initiation at PEG placement) to final visit (month 6 ± 15 days after hospital discharge). PDQ-39 summary index was standardized from 0 to 100, with a lower summary index indicating a better QoL.

Secondary endpoints for patients included the mean change from baseline to final visit in i) Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-III) score to evaluate motor impairment, measured during the best “On” time;63 ii) Non-Motor Symptoms Scale (NMSS) score;64 iii) Norris/Bond-Lader Visual Analog Scale (VAS) score (to evaluate the patient’s emotional well-being65); iv) 16-item Parkinson’s Fatigue Scale (PFS-16) score (cut-off of ≥3.30 was used to identify those perceiving fatigue to be a problem66); v) Apathy Scale (AS) score (patients with AS scores ≥14 were considered apathetic67); vi) Beck Depression Inventory-II (BDI-II) score;68 vii) Beck Anxiety Inventory (BAI) score;69 and viii) Treatment Satisfaction with Medicines-Questionnaire (SATMED-Q) score70.

For caregivers, endpoints included the mean change from baseline to final visit in i) Scale of Quality of Life of Caregivers (SQLC) score;71 ii) Zarit Burden Inventory (ZBI) score;72 iii) Caregiver Strain Index score;73 iv) Goldberg Anxiety and Depression Scale score;74,75 and v) Work Productivity and Activity Impairment (WPAI) score76.

Safety measures

Safety data were collected using ad-hoc forms for Serious Adverse Events (SAEs). The physician notified AbbVie (as the sponsor of the study) within 24 h of the physician becoming aware of the event. An adverse event was considered serious if resulted in death, was life threatening, required inpatient hospitalization or prolongation of existing hospitalization, resulted in persistent or significant disability/incapacity or caused congenital anomaly/birth defect. Nonserious adverse events were not collected for analysis and were communicated by the clinicians following usual clinical practice.

Statistical analysis

For sample size calculation, a minimal difference was assumed to detect 10% over a baseline score of 75.0 points in PDQ-39 based on the study of Lezcano et al.77. Assuming a standard deviation of 18.377, accepting an alpha risk of 0.05 and beta risk of 0.2 in a two-sided, 48 patients were needed to detect a difference equal to or greater than 7.5 units. Assuming a loss to follow up rate of 23% 59.2 patients are needed, so 60 patients are needed. Sample size calculation was performed with v GRANMO. 7.10. Statistical analyses were conducted using SAS® V9.4 software (SAS Institute, Cary, NC). For all analyses, a significance alpha (α) value equal to 0.05 was assumed. Continuous variables are presented as means and standard deviations (SD). The Shapiro-Wilk test was used to test whether variables followed a normal distribution. Categorical variables are reported using frequencies and percentages. Confidence intervals (95%) for the percentage were calculated, when required. The magnitude of change is represented as the relative change and paired Cohen’s effect size (0.20–0.49 = small effect; 0.50–0.79 = moderate effect; and 0.80 = large effect).

Descriptive statistics were calculated for demographic and clinical characteristics. Contrast statistics were used for intra-patient comparisons using repeated measures. In the case of continuous variables, the repeated measures Student t test or the Wilcoxon rank-sum test was used, depending on the normality of the data. In the case of binary qualitative variables, the chi-square test or the McNemar test was used. A mixed model of repeated measures was used for comparisons between visits.

Univariate analysis and multivariate linear regression analysis were used to assess the association between the change in PDQ-39 (dependent variable) and other variables (independent variables) UPDRS III, Unified Parkinson’s Disease Rating Scale-Part IV (UPDRS IV), NMSS, S&E, VAS, PFS-16, AS, BDI-II, BAI, SATMED-Q, SQCL and ZBI from baseline to 6 months (±15 days) after hospital discharge. Correlations have been evaluated using Pearson test (in case of continuous variables) or Spearman test (in case of ordinal variables). Those independent variables with P < 0.1 in the univariate analysis (all of them except UPDRS III, S&E and ZBI) without multicollinearity were included in the multivariate linear regression model. Statistical analyses were performed with the intent-to-treat and safety populations. Levodopa equivalent daily dose (LEDD), including levodopa daily dose plus all antiparkinsonian therapies, were calculated according to Tomlinson et al.78.

Study populations

The statistical analyses were performed in the following study populations:

  • Per Protocol population (PP): included those patients (and caregivers) who met all inclusion criteria and were classified as suitable on the levodopa/carbidopa continuous nasoduodenal catheter infusion test. Those patients had to complete the 6-month period of treatment, and at least, they had the quality of life data collected with the PDQ-39 questionnaire at baseline and after 6 months (±15 days) of treatment.

  • Intent-To-Treat (ITT) and Safety population: included those patients (and caregivers) that made up the PP population, those who were classified as not suitable on the levodopa/carbidopa continuous nasoduodenal catheter infusion test, and those that after undergoing the percutaneous endoscopic gastrostomy did not complete the 6-month treatment period.

As no significant differences were found between the two populations, only the results obtained in the ITT population are presented.

Reporting Summary

Further information on research design is available in the Nature Research Reporting Summary linked to this article.

Data availability

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols and Clinical Study Reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

This clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Sharing Agreement (DSA). Data requests can be submitted at any time and the data will be accessible for 12 months, with possible extensions considered. For more information on the process, or to submit a request, visit the following link:


  1. 1.

    Chapuis, S., Ouchchane, L., Metz, O., Gerbaud, L. & Durif, F. Impact of the motor complications of Parkinson’s disease on the quality of life. Mov. Disord. 20, 224–230 (2005).

    PubMed  Google Scholar 

  2. 2.

    Olanow, C. W. et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson’s disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13, 141–149 (2014).

    CAS  PubMed  Google Scholar 

  3. 3.

    Deuschl, G. et al. A randomized trial of deep-brain stimulation for Parkinson’s disease. N. Engl. J. Med. 355, 896–908 (2006).

    CAS  PubMed  Google Scholar 

  4. 4.

    Katzenschlager, R. et al. Apomorphine subcutaneous infusion in patients with Parkinson’s disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 17, 749–759 (2018).

    CAS  PubMed  Google Scholar 

  5. 5.

    Peto, V., Jenkinson, C., Fitzpatrick, R. & Greenhall, R. The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual. Life. Res. 4, 241–248 (1995).

    CAS  PubMed  Google Scholar 

  6. 6.

    Martinez-Martin, P. et al. Pallidotomy and quality of life in patients with Parkinson’s disease: an early study. Mov. Disord. 15, 65–70 (2000).

    CAS  PubMed  Google Scholar 

  7. 7.

    Nyholm, D. et al. Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease. Neurology 64, 216–223 (2005).

    CAS  PubMed  Google Scholar 

  8. 8.

    Antonini, A. et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s: Final results of the GLORIA registry. Parkinsonism Relat. Disord. 45, 13–20 (2017).

    PubMed  Google Scholar 

  9. 9.

    Nyholm, D., Jansson, R., Willows, T. & Remahl, I. N. Long-term 24-h duodenal infusion of levodopa: outcome and dose requirements. Neurology 65, 1506–1507 (2005).

    PubMed  Google Scholar 

  10. 10.

    Bohlega, S. et al. Levodopa-Carbidopa Intestinal Gel Infusion Therapy in Advanced Parkinson’s Disease: Single Middle Eastern Center Experience. Eur. Neurol. 74, 227–236 (2015).

    CAS  PubMed  Google Scholar 

  11. 11.

    Caceres-Redondo, M. T. et al. Long-term levodopa/carbidopa intestinal gel in advanced Parkinson’s disease. J. Neurol. 261, 561–569 (2014).

    CAS  PubMed  Google Scholar 

  12. 12.

    Honig, H. et al. Intrajejunal levodopa infusion in Parkinson’s disease: a pilot multicenter study of effects on nonmotor symptoms and quality of life. Mov. Disord. 24, 1468–1474 (2009).

    PubMed  Google Scholar 

  13. 13.

    Juhasz, A. et al. Levodopa/carbidopa intestinal gel can improve both motor and non-motor experiences of daily living in Parkinson’s disease: An open-label study. Parkinsonism Relat. Disord. 37, 79–86 (2017).

    PubMed  Google Scholar 

  14. 14.

    Kruger, R. et al. An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson’s Disease Patients. Adv. Ther. 34, 1741–1752 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Martinez-Martin, P. et al. EuroInf: a multicenter comparative observational study of apomorphine and levodopa infusion in Parkinson’s disease. Mov. Disord. 30, 510–516 (2015).

    CAS  PubMed  Google Scholar 

  16. 16.

    Reddy, P. et al. Intrajejunal levodopa versus conventional therapy in Parkinson disease: motor and nonmotor effects. Clin. Neuropharmacol. 35, 205–207 (2012).

    CAS  PubMed  Google Scholar 

  17. 17.

    Sensi, M. et al. Emerging issues on selection criteria of levodopa carbidopa infusion therapy: considerations on outcome of 28 consecutive patients. J. Neural Transm. (Vienna) 121, 633–642 (2014).

    CAS  Google Scholar 

  18. 18.

    Lopiano, L. et al. Motor and non-motor outcomes in patients with advanced Parkinson’s disease treated with levodopa/carbidopa intestinal gel: final results of the GREENFIELD observational study. J. Neurol. 266, 2164–2176 (2019).

    PubMed  PubMed Central  Google Scholar 

  19. 19.

    Ciurleo, R. et al. Assessment of Duodopa((R)) effects on quality of life of patients with advanced Parkinson’s disease and their caregivers. J. Neurol. 265, 2005–2014 (2018).

    PubMed  Google Scholar 

  20. 20.

    Antonini, A. et al. Duodenal levodopa infusion for advanced Parkinson’s disease: 12-month treatment outcome. Mov. Disord. 22, 1145–1149 (2007).

    PubMed  Google Scholar 

  21. 21.

    Antonini, A. et al. Duodenal levodopa infusion improves quality of life in advanced Parkinson’s disease. Neurodegener. Dis. 5, 244–246 (2008).

    CAS  PubMed  Google Scholar 

  22. 22.

    Chang, F. C. et al. Intraduodenal levodopa-carbidopa intestinal gel infusion improves both motor performance and quality of life in advanced Parkinson’s disease. J. Clin. Neurosci. 25, 41–45 (2016).

    CAS  PubMed  Google Scholar 

  23. 23.

    Devos, D. & French, D. S. G. Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson’s disease. Mov. Disord. 24, 993–1000 (2009).

    PubMed  Google Scholar 

  24. 24.

    De Fabregues, O. et al. Long-term safety and effectiveness of levodopa-carbidopa intestinal gel infusion. Brain Behav. 7, e00758 (2017).

    PubMed  PubMed Central  Google Scholar 

  25. 25.

    Fasano, A., Ricciardi, L., Lena, F., Bentivoglio, A. R. & Modugno, N. Intrajejunal levodopa infusion in advanced Parkinson’s disease: long-term effects on motor and non-motor symptoms and impact on patient’s and caregiver’s quality of life. Eur. Rev. Med. Pharmacol. Sci. 16, 79–89 (2012).

    CAS  PubMed  Google Scholar 

  26. 26.

    Fernandez, H. H. et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease: final 12-month, open-label results. Mov. Disord. 30, 500–509 (2015).

    CAS  PubMed  Google Scholar 

  27. 27.

    Foltynie, T. et al. Impact of Duodopa on Quality of Life in Advanced Parkinson’s Disease: A UK Case Series. Parkinsons Dis. 2013, 362908 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28.

    Isacson, D., Bingefors, K., Kristiansen, I. S. & Nyholm, D. Fluctuating functions related to quality of life in advanced Parkinson disease: effects of duodenal levodopa infusion. Acta Neurol. Scand. 118, 379–386 (2008).

    CAS  PubMed  Google Scholar 

  29. 29.

    Palhagen, S. E. et al. Levodopa-carbidopa intestinal gel (LCIG) treatment in routine care of patients with advanced Parkinson’s disease: An open-label prospective observational study of effectiveness, tolerability and healthcare costs. Parkinsonism Relat. Disord. 29, 17–23 (2016).

    PubMed  Google Scholar 

  30. 30.

    Puente, V. et al. Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson’s disease: impact on control of fluctuations and quality of life. Parkinsonism Relat. Disord. 16, 218–221 (2010).

    CAS  PubMed  Google Scholar 

  31. 31.

    Santos-Garcia, D., Anon, M. J., Fuster-Sanjurjo, L. & de la Fuente-Fernandez, R. Duodenal levodopa/carbidopa infusion therapy in patients with advanced Parkinson’s disease leads to improvement in caregivers’ stress and burden. Eur. J. Neurol. 19, 1261–1265 (2012).

    CAS  PubMed  Google Scholar 

  32. 32.

    Slevin, J. T. et al. Long-term safety and maintenance of efficacy of levodopa-carbidopa intestinal gel: an open-label extension of the double-blind pivotal study in advanced Parkinson’s disease patients. J. Parkinsons Dis. 5, 165–174 (2015).

    CAS  PubMed  Google Scholar 

  33. 33.

    Zibetti, M. et al. Long-term duodenal levodopa infusion in Parkinson’s disease: a 3-year motor and cognitive follow-up study. J. Neurol. 260, 105–114 (2013).

    CAS  PubMed  Google Scholar 

  34. 34.

    Standaert, D. G. et al. Effect of Levodopa-carbidopa Intestinal Gel on Non-motor Symptoms in Patients with Advanced Parkinson’s Disease. Mov. Disord. Clin. Pract. 4, 829–837 (2017).

    PubMed  PubMed Central  Google Scholar 

  35. 35.

    Barrett, B., Brown, D., Mundt, M. & Brown, R. Sufficiently important difference: expanding the framework of clinical significance. Med. Decis. Mak. 25, 250–261 (2005).

    Google Scholar 

  36. 36.

    Drapier, S. et al. Quality of life in Parkinson’s disease improved by apomorphine pump: the OPTIPUMP cohort study. J. Neurol. 263, 1111–1119 (2016).

    CAS  PubMed  Google Scholar 

  37. 37.

    Dafsari, H. S. et al. Subthalamic Stimulation Improves Quality of Life of Patients Aged 61 Years or Older With Short Duration of Parkinson’s Disease. Neuromodulation 21, 532–540 (2018).

    PubMed  Google Scholar 

  38. 38.

    Bellante, F., Dethy, S. & Zegers de Beyl, D. Depression, anxiety and non-motor symptoms on initiation of intrajejunal levodopa/carbidopa therapy. Acta Neurol. Belg. 116, 39–41 (2016).

    CAS  PubMed  Google Scholar 

  39. 39.

    Solla, P. et al. Dopamine agonist withdrawal syndrome (DAWS) symptoms in Parkinson’s disease patients treated with levodopa-carbidopa intestinal gel infusion. Parkinsonism Relat. Disord. 21, 968–971 (2015).

    PubMed  Google Scholar 

  40. 40.

    Lawrence, B. J., Gasson, N., Kane, R., Bucks, R. S. & Loftus, A. M. Activities of daily living, depression, and quality of life in Parkinson’s disease. PLoS One 9, e102294 (2014).

    PubMed  PubMed Central  Google Scholar 

  41. 41.

    Muller, B., Assmus, J., Herlofson, K., Larsen, J. P. & Tysnes, O. B. Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson’s disease. Parkinsonism Relat. Disord. 19, 1027–1032 (2013).

    PubMed  Google Scholar 

  42. 42.

    Rahman, S., Griffin, H. J., Quinn, N. P. & Jahanshahi, M. Quality of life in Parkinson’s disease: the relative importance of the symptoms. Mov. Disord. 23, 1428–1434 (2008).

    PubMed  Google Scholar 

  43. 43.

    Schrag, A. Quality of life and depression in Parkinson’s disease. J. Neurol. Sci. 248, 151–157 (2006).

    PubMed  Google Scholar 

  44. 44.

    Soh, S. E., Morris, M. E. & McGinley, J. L. Determinants of health-related quality of life in Parkinson’s disease: a systematic review. Parkinsonism Relat. Disord. 17, 1–9 (2011).

    PubMed  Google Scholar 

  45. 45.

    Barone, P. et al. The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov. Disord. 24, 1641–1649 (2009).

    PubMed  Google Scholar 

  46. 46.

    Prakash, K. M., Nadkarni, N. V., Lye, W. K., Yong, M. H. & Tan, E. K. The impact of non-motor symptoms on the quality of life of Parkinson’s disease patients: a longitudinal study. Eur. J. Neurol. 23, 854–860 (2016).

    CAS  PubMed  Google Scholar 

  47. 47.

    Havlikova, E. et al. Impact of fatigue on quality of life in patients with Parkinson’s disease. Eur. J. Neurol. 15, 475–480 (2008).

    CAS  PubMed  Google Scholar 

  48. 48.

    Skorvanek, M. et al. Relationship between the non-motor items of the MDS-UPDRS and Quality of Life in patients with Parkinson’s disease. J. Neurol. Sci. 353, 87–91 (2015).

    PubMed  Google Scholar 

  49. 49.

    Skorvanek, M. et al. Apathy in elderly nondemented patients with Parkinson’s disease: clinical determinants and relationship to quality of life. J. Geriatr. Psychiatry Neurol. 26, 237–243 (2013).

    PubMed  Google Scholar 

  50. 50.

    Hanna, K. K. & Cronin-Golomb, A. Impact of anxiety on quality of life in Parkinson’s disease. Parkinsons Dis. 2012, 640707 (2012).

    PubMed  Google Scholar 

  51. 51.

    Santos-Garcia, D. & de la Fuente-Fernandez, R. Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson’s disease. J. Neurol. Sci. 332, 136–140 (2013).

    PubMed  Google Scholar 

  52. 52.

    Berganzo, K. et al. Motor and non-motor symptoms of Parkinson’s disease and their impact on quality of life and on different clinical subgroups. Neurologia 31, 585–591 (2016).

    CAS  PubMed  Google Scholar 

  53. 53.

    Ramaker, C., Marinus, J., Stiggelbout, A. M. & Van Hilten, B. J. Systematic evaluation of rating scales for impairment and disability in Parkinson’s disease. Mov. Disord. 17, 867–876 (2002).

    PubMed  Google Scholar 

  54. 54.

    Shulman, L. M. et al. Disability Rating Scales in Parkinson’s Disease: Critique and Recommendations. Mov. Disord. 31, 1455–1465 (2016).

    PubMed  Google Scholar 

  55. 55.

    Meara, J., Mitchelmore, E. & Hobson, P. Use of the GDS-15 geriatric depression scale as a screening instrument for depressive symptomatology in patients with Parkinson’s disease and their carers in the community. Age Ageing 28, 35–38 (1999).

    CAS  PubMed  Google Scholar 

  56. 56.

    Leroi, I., McDonald, K., Pantula, H. & Harbishettar, V. Cognitive impairment in Parkinson disease: impact on quality of life, disability, and caregiver burden. J. Geriatr. Psychiatry Neurol. 25, 208–214 (2012).

    PubMed  Google Scholar 

  57. 57.

    Lawson, R. A. et al. Cognitive impairment in Parkinson’s disease: impact on quality of life of carers. Int. J. Geriatr. Psychiatry. 32, 1362–1370 (2016).

    PubMed  PubMed Central  Google Scholar 

  58. 58.

    Crespo-Burillo, J. A. et al. Deep brain stimulation for patients with Parkinson’s disease: Effect on caregiver burden. Neurologia 33, 154–159 (2018).

    CAS  PubMed  Google Scholar 

  59. 59.

    Santos-Garcia, D. & de la Fuente-Fernandez, R. Factors contributing to caregivers’ stress and burden in Parkinson’s disease. Acta Neurol. Scand. 131, 203–210 (2015).

    CAS  PubMed  Google Scholar 

  60. 60.

    Hughes, A. J., Daniel, S. E., Kilford, L. & Lees, A. J. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55, 181–184 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  61. 61.

    Dubois, B. et al. Diagnostic procedures for Parkinson’s disease dementia: recommendations from the movement disorder society task force. Mov. Disord. 22, 2314–2324 (2007).

    PubMed  Google Scholar 

  62. 62.

    Jenkinson, C., Fitzpatrick, R., Peto, V., Greenhall, R. & Hyman, N. The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing 26, 353–357 (1997).

    CAS  PubMed  Google Scholar 

  63. 63.

    Goetz, C. G. et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. 23, 2129–2170 (2008).

    PubMed  PubMed Central  Google Scholar 

  64. 64.

    Martinez-Martin, P. et al. International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73, 1584–1591 (2009).

    CAS  PubMed  Google Scholar 

  65. 65.

    Bond, A. & Lader, M. The use of analogue scales in rating subjective feelings. Br. J. Med. Psychol. 47, 211–218 (1974).

    Google Scholar 

  66. 66.

    Brown, R. G., Dittner, A., Findley, L. & Wessely, S. C. The Parkinson fatigue scale. Parkinsonism Relat. Disord. 11, 49–55 (2005).

    CAS  PubMed  Google Scholar 

  67. 67.

    Starkstein, S. E. et al. Reliability, validity, and clinical correlates of apathy in Parkinson’s disease. J. Neuropsychiatry Clin. Neurosci. 4, 134–139 (1992).

    CAS  PubMed  Google Scholar 

  68. 68.

    Beck, A., Steer, R. & Garbin, M. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clin. Psych. Rev. 8, 77–100 (1988).

    Google Scholar 

  69. 69.

    Beck, A. T., Epstein, N., Brown, G. & Steer, R. A. An inventory for measuring clinical anxiety: psychometric properties. J. Consult. Clin. Psychol. 56, 893–897 (1988).

    CAS  PubMed  Google Scholar 

  70. 70.

    Ruiz, M. A. et al. Development and validation of the “Treatment Satisfaction with Medicines Questionnaire” (SATMED-Q). Value Health 11, 913–926 (2008).

    PubMed  Google Scholar 

  71. 71.

    Glozman, J. M., Bicheva, K. G. & Fedorova, N. V. Scale of Quality of Life of Care-Givers (SQLC). J. Neurol. 245(Suppl 1), S39–41 (1998).

    PubMed  Google Scholar 

  72. 72.

    Zarit, S. H., Reever, K. E. & Bach-Peterson, J. Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist 20, 649–655 (1980).

    CAS  PubMed  Google Scholar 

  73. 73.

    Robinson, B. C. Validation of a Caregiver Strain Index. J. Gerontol. 38, 344–348 (1983).

    CAS  PubMed  Google Scholar 

  74. 74.

    Goldberg, D., Bridges, K., Duncan-Jones, P. & Grayson, D. Detecting anxiety and depression in general medical settings. BMJ 297, 897–899 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  75. 75.

    Monton, C., Perez Echeverria, M. J., Campos, R., Garcia Campayo, J. & Lobo, A. [Anxiety scales and Goldberg’s depression: an efficient interview guide for the detection of psychologic distress]. Aten. Primaria 12, 345–349 (1993).

    CAS  PubMed  Google Scholar 

  76. 76.

    Tang, K., Beaton, D. E., Boonen, A., Gignac, M. A. & Bombardier, C. Measures of work disability and productivity: Rheumatoid Arthritis Specific Work Productivity Survey (WPS-RA), Workplace Activity Limitations Scale (WALS), Work Instability Scale for Rheumatoid Arthritis (RA-WIS), Work Limitations Questionnaire (WLQ), and Work Productivity and Activity Impairment Questionnaire (WPAI). Arthritis Care Res. (Hoboken) 63(Suppl 11), S337–349 (2011).

    Google Scholar 

  77. 77.

    Lezcano, E. et al. Improvement in quality of life in patients with advanced Parkinson’s disease following bilateral deep-brain stimulation in subthalamic nucleus. Eur. J. Neurol. 11, 451–454 (2004).

    CAS  PubMed  Google Scholar 

  78. 78.

    Tomlinson, C. L. et al. Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Mov. Disord. 25, 2649–2653 (2010).

    PubMed  Google Scholar 

Download references


We thank Vanesa Vera at Pivotal, S.L.U. (Madrid, Spain) for statistical analysis assistance, and Angel Burgos at Pivotal, S.L.U. for editing the manuscript and editorial writing assistance. These services were funded by AbbVie S.L.U. We would like to recognize the contributions of the principal investigators: Son Espases Hospital: Bárbara Vives; Santa Creu i Sant Pau Hospital: Berta Pascual; San Pedro Alcántara Hospital: Gonzalo Gámez-Leyva; La Fe Hospital: Irene Martínez; Valladolid Hospital: Javier Marco; Virgen Macarena Hospital: José Manuel García; Santa Lucía Hospital: Juan José Soria; Navarra Hospital Center: Pedro Luis Clavero, Mª Iciar Gastón; Elche General Hospital: María Álvarez; San Pedro Alcántara Hospital: Montserrat Gómez; Vall D´Hebron Hospital: Oriol de Fàbregues; Puerta del Mar Hospital: Miguel Moya, Raúl Espinosa; Parc Tauli Hospital: Tania Delgado. The study was sponsored by AbbVie, S.L.U. The design, study conduct, and financial support for the ADEQUA study were provided by AbbVie. AbbVie participated in the research, data collection, analysis and interpretation of data, writing, reviewing, and approving the publication.

Author information




Authors’ roles include but are not restricted to: 1. Research project: A. Conception, B. Organization, C. Execution. 2. Statistical Analysis: A. Design, B. Execution, C. Review and Critique. 3. Manuscript Preparation: A. Writing of the first draft, B. Review and Critique. Francesc Valldeoriola: 2C, 3B M.J.C.: 2C, 3B. E.F.: 2C, 3B. J.O.: 2C, 3B. E.C.: 2C, 3B. D.S.G.: 2C, 3B. M.C.: 2C, 3B. P.M-M.: 2C, 3B. J.C.P.: 1A, 1B, 1C, 2C, 3B. G.A.: 1A, 1B, 1C, 2C, 3B. J.M.A.: 2C, 3B.

Corresponding author

Correspondence to Francesc Valldeoriola.

Ethics declarations

Competing interests

The author declares no competing interests. The disclosures of the authors are: F. Valldeoriola has received honoraria for speaking services and advisory boards from AbbVie, Zambon, Teva, Medtronic, and Boston Scientific. M.J. Catalán has received honoraria for consulting, advisory services, speaking services, and research from AbbVie Laboratories and Merz. F. Escamilla-Sevilla has received honoraria for advisory services, consulting, lecturing, support in assisting scientific meetings, and research from AbbVie, Italfarmaco, Medtronic, Merz, Teva, UCB Pharma, and Zambon. E. Freire has received honoraria from AbbVie, UCB, Zambon, Bial, and Eisai. J. Olivares has received honoraria in 2016 from AbbVie, UCB, Zambon, Teva, and Eisai. E. Cubo has received honoraria from AbbVie and Zambon. D. Santos Garcia has received honoraria from AbbVie, UCB Pharma, Teva, Zambon, KRKA, and Lundbeck. M. Calopa has received honoraria from AbbVie and Zambon. P. Martínez-Martín has received honoraria from National School of Public Health (ISCIII), Britannia, and Editorial Viguera for lecturing in courses; International Parkinson and Movement Disorder Society for management of the Program on Rating Scales; Bial, and Zambon for advice in clinical-epidemiological studies. Financial support by the International Parkinson and Movement Disorder Society for attending the IPMDS International Congress 2019. Grant for Research: International Parkinson and Movement Disorder Society, for development and validation of the MDS-NMS. J.C. Parra is an employee of AbbVie and holds AbbVie stock and/or stock options. G. Arroyo is an employee of AbbVie. J.M. Arbelo has received honoraria from AbbVie, Zambon, Bial, and Teva.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Valldeoriola, F., Catalán, M.J., Escamilla-Sevilla, F. et al. Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson’s disease. npj Parkinsons Dis. 7, 108 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing