Fig. 3: The genotype of reference SVAs was associated with differential gene expression. | npj Parkinson's Disease

Fig. 3: The genotype of reference SVAs was associated with differential gene expression.

From: Reference SVA insertion polymorphisms are associated with Parkinson’s Disease progression and differential gene expression

Fig. 3

a At 0 months a 1.3 fold change in expression of FLACC1 was significantly associated with SVA_11 genotype when comparing PP to AA (FDR p = 0.04) and at 36 months a 1.4 fold change in expression when comparing PP to AA (FDR p = 2.22 × 10−5). b At 0 months a 3 fold change in expression of HLA-A was significantly associated with SVA_24 genotype when comparing PA to AA (FDR p = 1.90 × 10−78) and a 3.7 fold change in expression when comparing PP to AA (FDR p = 6.22 × 10−51). At 36 months a 2.5 fold change in expression of HLA-A was significantly associated with SVA_24 genotype when comparing PA to AA (FDR p = 7.51 × 10−60) and a 3.6 fold change in expression when comparing PP to AA (FDR p = 2.49 × 10−38). n = 608.

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