Table 1 Used genome-wide association studies and consortia in the present study.

From: Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study

Trait Unit SNPs F-statistic Participants Adjustments PubMed ID or web-link
Serum calcium mg/dL (rescaled to 1 SD, equivalent to 0.5 mg/dL) 7 74 Up to 61,079 European-descent individuals Age, sex and study-specific covariates (e.g., principal components and study center) 24068962
Blood triglycerides SD 440 117 441,016 European-descent individuals Age, sex and a binary variable denoting the genotyping chip 32203549
Smoking initiation SD in prevalence of smoking initiation 378 46 1,232,091 European-descent individuals Age, sex and the first ten genetic principal components 30643251
Alcohol consumption SD increase of log-transformed alcoholic drinks/week 99 65 941,280 European-descent individuals Age, sex and the first ten genetic principal components 30643251
Type 2 diabetes One-unit in prevalence of type 2 diabetes 558 91 228,499 type 2 diabetes cases and 1,178,783 non-cases of multiancestries Age, sex and the first ten genetic principal components 32541925
Gallstone disease One-unit in prevalence of gallstone disease 32 130 27,174 gallstone disease cases and 736,838 non-cases of European ancestry Unknown 30504769
Acute pancreatitis 1292 cases and 359,902 non-cases of British ancestry Age, sex and up to 20 genetic principal components UK Biobank (http://www.nealelab.is/uk-biobank)
Chronic pancreatitis 246 cases and 360,948 non-cases of British ancestry Age, sex and up to 20 genetic principal components UK Biobank (http://www.nealelab.is/uk-biobank)
Acute pancreatitis 1762 cases and 121,348 non-cases of Finnish ancestry Age, sex, 10 genetic principal components and genotyping batch FinnGen consortium (https://www.finngen.fi/fi)
Chronic pancreatitis 914 cases and 121,348 non-cases of Finnish ancestry Age, sex, 10 genetic principal components and genotyping batch FinnGen consortium (https://www.finngen.fi/fi)
  1. PubMed ID indicates PubMed identifier.
  2. SD standard deviation, SNP single-nucleotide polymorphisms.