Fig. 2: Publicly available breast cancer gene expression datasets recapitulate some epidemiological trends, but have reduced proportions of ER+ and grade 1 tumors compared with Western populations. | npj Breast Cancer

Fig. 2: Publicly available breast cancer gene expression datasets recapitulate some epidemiological trends, but have reduced proportions of ER+ and grade 1 tumors compared with Western populations.

From: Breast cancer gene expression datasets do not reflect the disease at the population level

Fig. 2

The distribution of molecular subtypes by age (a) and the association between BMI and molecular predictions of poor outcomes (b) are as would be expected. However, Asians older than 50 appear to have worse predicted prognosis than other races (c), but this is likely confounded by other factors. The boxes represent upper and lower quartile ranges, horizontal line the median and whiskers indicate 1.5× the interquartile range. Incidence rates for ER-positive tumors progressively increase overtime, but the proportion remains significantly lower than that reported by SEER (d), vertical bars represent 95% confidence intervals. Grade 3 tumors were most abundant in publicly available datasets for the 1990s, which does not reflect SEER figures, which show increasing proportions of grade 1 tumors over the last three decades (e).

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