Fig. 2 | npj Biofilms and Microbiomes

Fig. 2

From: The rumen microbiome: an underexplored resource for novel antimicrobial discovery

Fig. 2

Antimicrobial activity and haemolytic activity of Lynronne-1, Lynronne-2 and Lynronne-3. a Time-dependent kill of MRSA USA300 by antimicrobial compounds at 3× MIC concentration. Dashed lines indicate limit of detection. b Resistance acquisition during serial passaging of MRSA USA300 cells in the presence of sub-MIC levels of antimicrobials. The y axis is the fold change in MIC during passaging. For mupirocin, 256× MIC was the highest concentration tested. The figure is representative of three independent experiments. c Quantification of anti-biofilm activity (MRSA 33591): * and ** P < 0.05 and 0.01 respectively—significantly different from untreated cells (positive). d Haemolytic activity, dashed line indicates 50% haemolysis. Values from at least three independent replicates; error bars represent the standard deviation)

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