Fig. 3 | npj Aging and Mechanisms of Disease

Fig. 3

From: Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

Fig. 3

Amyloid plaque deposition in the cortex and hippocampus of APP-Tg mice. a Immunostaining of Aβ in brain sections. b Aβ loads in brain sections. Results are expressed as means ± S.D., **p < 0.01. c Aβ40 and Aβ42 in the cortex and hippocampus of P. gingivalis-infected APP-Tg mice. Concentrations of Aβ40 and Aβ42 in the extracts of brain were measured by ELISA. Control: Mice inoculated with CMC alone, P. gingivalis: Mice inoculated with CMC and P. gingivalis. Results are expressed as means ± S.D., *p < 0.05. d TNF-α and IL-1β in the brain in P. gingivalis-infected APP-Tg mice. Amounts of TNF-α and IL-1β in brain extracts were measured by ELISA. Results are expressed as means ± S.D., *p < 0.05, **p < 0.01

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