A tethering approach based on a LexA–CENH3 fusion protein in maize activates functional centromeres at synthetic LexO repeat arrays. The synthetic centromeres cause fragmentation of the resulting dicentric chromosomes, resulting in stably inherited and self-sustaining neochromosomes.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Dawe, R. K. et al. Nat. Plants https://doi.org/10.1038/s41477-023-01370-8 (2023).
McKinley, K. L. & Cheeseman, I. M. Nat. Rev. Mol. Cell Biol. 17, 16–29 (2016).
Karpen, G. H. & Allshire, R. C. Trends Genet. 13, 489–496 (1997).
Henikoff, S., Ahmad, K. & Malik, H. S. Science 293, 1098–1102 (2001).
Melters, D. P. et al. Genome Biol. 14, R10 (2013).
Thakur, J., Packiaraj, J. & Henikoff, S. Int. J. Mol. Sci. 22, 4309 (2021).
Scott, K. C. & Sullivan, B. A. Trends Genet. 30, 66–74 (2014).
McClintock, B. Genetics 26, 234–282 (1941).
Presting, G. G. Curr. Opin. Genet. Dev. 49, 79–84 (2018).
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Henderson, I.R. Creating synthetic maize centromeres. Nat. Plants 9, 379–380 (2023). https://doi.org/10.1038/s41477-023-01366-4