A tethering approach based on a LexA–CENH3 fusion protein in maize activates functional centromeres at synthetic LexO repeat arrays. The synthetic centromeres cause fragmentation of the resulting dicentric chromosomes, resulting in stably inherited and self-sustaining neochromosomes.
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Henderson, I.R. Creating synthetic maize centromeres. Nat. Plants 9, 379–380 (2023). https://doi.org/10.1038/s41477-023-01366-4
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DOI: https://doi.org/10.1038/s41477-023-01366-4
