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Make it a Combo

Same Cas9 protein, two different jobs: the CRISPR-Combo genome engineering strategy enables simultaneous gene activation and genome editing for different targets through changes to the guide RNA structure.

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Fig. 1: Strategy and applications of the CRISPR-Combo system in plants.


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Correspondence to Juan M. Debernardi or Beth A. Rowan.

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The authors declare no competing interests.

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Debernardi, J.M., Rowan, B.A. Make it a Combo. Nat. Plants 8, 457–458 (2022).

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