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Noise-cancelling translation syncs cellular clocks

Theory and single-cell experiments outline a new role for upstream open reading frames in buffering cellular heterogeneity in protein abundance at the translation level.

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Fig. 1: Model for uORF-mediated noise reduction in protein abundance via translational repression.

References

  1. Nick, P., Ehmann, B., Furuya, M. & Schafer, E. Plant Cell 5, 541–552 (1993).

    Article  CAS  Google Scholar 

  2. Hillmer, S., Gilroy, S. & Jones, R. L. Plant Physiol 102, 279–286 (1993).

    Article  CAS  Google Scholar 

  3. Abley, K. & Locke, J. C. W. Nat. Plants 7, 996–997 (2021).

    Article  CAS  Google Scholar 

  4. Cortijo, S. & Locke, J. C. W. Trends in Plant Sci. 25, 1041–1051 (2020).

    Article  CAS  Google Scholar 

  5. Wu et al. Nat. Plants https://doi.org/10.1038/s41477-022-01136-8 (2022).

  6. Maamar, H., Raj, A. & Dubnau, D. Science 317, 526–529 (2007).

    Article  CAS  Google Scholar 

  7. Meyer, H. M. et al. eLife 1, e19131 (2017).

    Article  Google Scholar 

  8. El Meouche, I., Siu, Y. & Dunlop, M. J. Sci. Rep. 13, 19538 (2016).

    Article  Google Scholar 

  9. Shaffer, S. M. et al. Nature 15, 431–435 (2017).

    Article  Google Scholar 

  10. Phillips, R. et al. Annu. Rev. Biophys. 6, 121–163 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Simon Alamos.

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Alamos, S. Noise-cancelling translation syncs cellular clocks. Nat. Plants 8, 455–456 (2022). https://doi.org/10.1038/s41477-022-01143-9

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