Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

DEFENCE PRIMING

Sp(l)icing up PepR signalling

Alternative splicing provides a fundamental and ubiquitous mechanism of gene regulation. Stimuli-induced retention of introns introduces novel proteoforms with altered signalling output: full-length CPK28 blocks immune signalling, while a truncated variant, lacking calcium responsiveness, promotes it.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: PepR-induced alternative splicing overrides post-translational modification (PTM)-controlled immune suppression to allow response amplification.

References

  1. 1.

    Ross, A. et al. EMBO J. 33, 62–75 (2014).

    CAS  Article  Google Scholar 

  2. 2.

    Hander, T. et al. Science 363, eaar7486 (2019).

  3. 3.

    Wang, J. et al. Mol. Cell 69, 493–504 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Monaghan, J. et al. Cell Host Microbe 16, 605–615 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Dressano, K. et al. Nat. Plants https://doi.org/10.1038/s41477-020-0724-1 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Ding, F. et al. BMC Genomics 15, 431 (2014).

    Article  Google Scholar 

  7. 7.

    Hake, K. & Romeis, T. Plant Cell Environ. 42, 904–917 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Bazin, J. et al. PLoS Pathog. 16, e1008401 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Bender, K. W. et al. J. Biol. Chem. 292, 3988–4002 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Lennart Wirthmueller or Tina Romeis.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wirthmueller, L., Romeis, T. Sp(l)icing up PepR signalling. Nat. Plants 6, 912–913 (2020). https://doi.org/10.1038/s41477-020-0708-1

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing