The calcium ion (Ca2+) is a universal signal in all eukaryotic cells. A fundamental question is how Ca2+, a simple cation, encodes complex information with high specificity. Extensive research has established a two-step process (encoding and decoding) that governs the specificity of Ca2+ signals. While the encoding mechanism entails a complex array of channels and transporters, the decoding process features a number of Ca2+ sensors and effectors that convert Ca2+ signals into cellular effects. Along this general paradigm, some signalling components may be highly conserved, but others are divergent among different organisms. In plant cells, Ca2+ participates in numerous signalling processes, and here we focus on the latest discoveries on Ca2+-encoding mechanisms in development and biotic interactions. In particular, we use examples such as polarized cell growth of pollen tube and root hair in which tip-focused Ca2+ oscillations specify the signalling events for rapid cell elongation. In plant–microbe interactions, Ca2+ spiking and oscillations hold the key to signalling specificity: while pathogens elicit cytoplasmic spiking, symbiotic microorganisms trigger nuclear Ca2+ oscillations. Herbivore attacks or mechanical wounding can trigger Ca2+ waves traveling a long distance to transmit and convert the local signal to a systemic defence program in the whole plant. What channels and transporters work together to carve out the spatial and temporal patterns of the Ca2+ fluctuations? This question has remained enigmatic for decades until recent studies uncovered Ca2+ channels that orchestrate specific Ca2+ signatures in each of these processes. Future work will further expand the toolkit for Ca2+-encoding mechanisms and place Ca2+ signalling steps into larger signalling networks.
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Research in authors’ laboratories is supported by National Key Research and Development Program of China (grant YFD0300102-3 to L.L.), National Natural Science Foundation of China (grants 31930010 and 31872170 to L.L.), the National Science Foundation (grant 1714795 to S.L.), and a grant from the Innovative Genomics Institute of California (to S.L.). C.W. is supported by Tang Distinguished Scholarship, University of California at Berkeley.
The authors declare no competing interests.
Peer review information Nature Plants thanks Jean-Philippe Galaud, Kiwamu Tanaka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Tian, W., Wang, C., Gao, Q. et al. Calcium spikes, waves and oscillations in plant development and biotic interactions. Nat. Plants 6, 750–759 (2020). https://doi.org/10.1038/s41477-020-0667-6
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