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Plant genome editing branches out

The budding field of precision genome editing in plants expands with an engineered CRISPR–Cas9 variant named SpRY, which enables mutagenesis of virtually any genomic sequence.

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Fig. 1: SpRY enables versatile genome editing by relaxing the PAM constraint.


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Correspondence to Benjamin P. Kleinstiver.

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Competing interests

B.P.K. is an inventor on patent applications filed by Mass General Brigham that describe genome engineering technologies, is an advisor to Acrigen Biosciences and consults for Avectas Inc. and ElevateBio. L.T.H. declares no competing interests.

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Hille, L.T., Kleinstiver, B.P. Plant genome editing branches out. Nat. Plants 7, 4–5 (2021).

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