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GENOME ENGINEERING

Plant genome editing branches out

Nature Plants volume 7, pages 4–5 (2021)Cite this article

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The budding field of precision genome editing in plants expands with an engineered CRISPR–Cas9 variant named SpRY, which enables mutagenesis of virtually any genomic sequence.

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Fig. 1: SpRY enables versatile genome editing by relaxing the PAM constraint.

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Authors and Affiliations

  1. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

    Logan T. Hille & Benjamin P. Kleinstiver

  2. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

    Logan T. Hille & Benjamin P. Kleinstiver

  3. PhD Program in Biological and Biomedical Sciences, Harvard University, Boston, MA, USA

    Logan T. Hille

  4. Department of Pathology, Harvard Medical School, Boston, MA, USA

    Benjamin P. Kleinstiver

Authors
  1. Logan T. Hille
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  2. Benjamin P. Kleinstiver
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Correspondence to Benjamin P. Kleinstiver.

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Competing interests

B.P.K. is an inventor on patent applications filed by Mass General Brigham that describe genome engineering technologies, is an advisor to Acrigen Biosciences and consults for Avectas Inc. and ElevateBio. L.T.H. declares no competing interests.

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Hille, L.T., Kleinstiver, B.P. Plant genome editing branches out. Nat. Plants 7, 4–5 (2021). https://doi.org/10.1038/s41477-020-00840-7

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