PLANT IMMUNITY

Deceiving the chaperone

Heat-shock protein 90 (HSP90) chaperones play an essential role in plant defence by assisting the folding of client proteins needed for immunity. A newly identified bacterial effector promotes disease by mimicking a HSP90 client, functioning as a minimal kinase that phosphorylates and inactivates the chaperone.

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Fig. 1: A schematic model on the disruption of HSP90’s function in plant defence by the bacterial type III effector HopBF1.

References

  1. 1.

    Weinhold, A. R. Annu. Rev. Phytopathol. 34, 1–11 (1996).

    CAS  Article  Google Scholar 

  2. 2.

    Jones, J. D. & Dangl, J. L. Nature 444, 323–329 (2006).

    CAS  Article  Google Scholar 

  3. 3.

    Toruno, T. Y., Stergiopoulos, I. & Coaker, G. Annu. Rev. Phytopathol. 54, 419–441 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Lopez, V. A. et al. Cell 179, 205–218 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Mayor, A., Martinon, F., De Smedt, T., Petrilli, V. & Tschopp, J. Nat. Immunol. 8, 497–503 (2007).

    CAS  Article  Google Scholar 

  6. 6.

    Martine, P. & Rébé, C. Int. J. Mol. Sci. 20, 4508 (2019).

    Article  Google Scholar 

  7. 7.

    Shirasu, K. Annu. Rev. Plant Biol. 60, 139–164 (2009).

    CAS  Article  Google Scholar 

  8. 8.

    Wu, L., Chen, H., Curtis, C. & Fu, Z. Q. Virulence 5, 710–721 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Schopf, F. H., Biebl, M. M. & Buchner, J. Nat. Rev. Mol. Cell Bio. 18, 345–360 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Rowlands, M. et al. J. Biomol. Screen. 15, 279–286 (2010).

    CAS  Article  Google Scholar 

  11. 11.

    Cui, H. et al. Cell Host Microbe 7, 164–175 (2010).

    CAS  Article  Google Scholar 

  12. 12.

    Wu, M. & Hardwidge, P. R. Pathogens 7, 87 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Fengquan Liu or Zheng Qing Fu.

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Chen, H., Liu, F. & Fu, Z.Q. Deceiving the chaperone. Nat. Plants 5, 1110–1111 (2019). https://doi.org/10.1038/s41477-019-0552-3

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