Deceiving the chaperone

Heat-shock protein 90 (HSP90) chaperones play an essential role in plant defence by assisting the folding of client proteins needed for immunity. A newly identified bacterial effector promotes disease by mimicking a HSP90 client, functioning as a minimal kinase that phosphorylates and inactivates the chaperone.

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Fig. 1: A schematic model on the disruption of HSP90’s function in plant defence by the bacterial type III effector HopBF1.


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Correspondence to Fengquan Liu or Zheng Qing Fu.

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Chen, H., Liu, F. & Fu, Z.Q. Deceiving the chaperone. Nat. Plants 5, 1110–1111 (2019).

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