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DNA methylation makes mutational history

A quantitative phylogenetic association mapping approach links genic mutational spectra to the evolution of DNA methylation in the Brassicaceae family of flowering plants. The method has wider applications and may usher in a new era in our understanding of species diversity.

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Fig. 1: CMT3-mediated evolution of gbM shapes the mutational spectrum of genes.


  1. Zemach, A., McDaniel, I. E., Silva, P. & Zilberman, D. Science 14, 916–919 (2010).

    Article  Google Scholar 

  2. Feng, S. et al. Proc. Natl Acad. Sci. USA 107, 8689–8694 (2010).

    Article  CAS  Google Scholar 

  3. Takuno, S. & Gaut, B. S. Proc. Natl Acad. Sci. USA 110, 1797–1802 (2013).

    Article  CAS  Google Scholar 

  4. Niederhuth, C. E. et al. Genome Biol. 17, 194 (2016).

    Article  Google Scholar 

  5. Horvath, R., Laenen, B., Takun, S. & Slotte, T. Heredity 123, 81–91 (2019).

    Article  CAS  Google Scholar 

  6. Zilberman, D. Genome Biol. 18, 87 (2017).

    Article  Google Scholar 

  7. Bewick, A. J. et al. Proc. Natl Acad. Sci. USA 113, 9111–9116 (2016).

    Article  CAS  Google Scholar 

  8. Vidalis, A. et al. Genome Biol. 17, 264 (2016).

    Article  Google Scholar 

  9. Willing, E. M. et al. Nat. Plants (2019).

  10. Bewick, A. J. et al. Genome Biol. 18, 65 (2017).

    Article  Google Scholar 

  11. Vlad, D. et al. Science 343, 780–783 (2014).

    Article  CAS  Google Scholar 

  12. Hiller, M. et al. Cell Rep. 2, 817–823 (2012).

    Article  CAS  Google Scholar 

  13. Delaux, P.-M. et al. PLoS Genet. 10, e1004487 (2014).

    Article  Google Scholar 

  14. Griesmann, M. et al. Science 361, eaat1743 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Frank Johannes.

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Johannes, F. DNA methylation makes mutational history. Nat. Plants 5, 772–773 (2019).

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