Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PROTEIN EVOLUTION

Tinker, tailor, soldier, enzyme

Nature Plants volume 3, pages 848–849 (2017)Cite this article

Subjects

Enzymes are a great example of the tight link between sequence, structure and function. A recent study of two dehydrogenases shows exactly how small changes in sequence can have great impacts on function.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Enzymes and enzyme families are hubs for function and regulation.

References

  1. Schenck, C.  A. et al. Nat. Chem. Biol. 13, 1029–1035 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. El-Azaz, J., de la Torre, F., Ávila, C. & Cánovas, F. M. Plant J. 87, 215–229 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Mendonça, L. M. F. & Marana, S. R. Biochim. Biophys. Acta 1814, 1616–1623 (2011).

    Article  PubMed  Google Scholar 

  4. Huang, J. et al. Plant Physiol. 153, 1526–1538 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Jeffery, C. J. in Molecular Chaperones and Cell Signalling (eds Henderson, B. & Pockley, A. G.) 61–77 (Cambridge Univ. Press, Cambridge, 2005).

  6. Jeffery, C. J. J. Proteom. 134, 19–24 (2016).

    Article  CAS  Google Scholar 

  7. Braun, P. & Gingras, A.-C. Proteomics 12, 1478–1498 (2012).

    Article  CAS  PubMed  Google Scholar 

  8. Jacob, F. Science 196, 1161–1166 (1977).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Western University, London, Ontario, Canada

    Susanne E. Kohalmi & Emily J. Clayton

Authors
  1. Susanne E. Kohalmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emily J. Clayton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susanne E. Kohalmi.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kohalmi, S.E., Clayton, E.J. Tinker, tailor, soldier, enzyme. Nature Plants 3, 848–849 (2017). https://doi.org/10.1038/s41477-017-0047-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41477-017-0047-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing