PROTEIN EVOLUTION

Tinker, tailor, soldier, enzyme

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Enzymes are a great example of the tight link between sequence, structure and function. A recent study of two dehydrogenases shows exactly how small changes in sequence can have great impacts on function.

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Fig. 1: Enzymes and enzyme families are hubs for function and regulation.

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Correspondence to Susanne E. Kohalmi.

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Kohalmi, S.E., Clayton, E.J. Tinker, tailor, soldier, enzyme. Nature Plants 3, 848–849 (2017). https://doi.org/10.1038/s41477-017-0047-z

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