PLANT EPIGENOMICS

Hybrids in the chromatin

New genomic maps reveal that R-loop structures formed upon hybridization of nascent RNA transcripts to the DNA template are a common characteristic of Arabidopsis chromatin that may have a broad impact on gene expression.

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Fig. 1: The hybridization of the nascent RNA transcript (in red) to the DNA template creates so-called R-loop structures.

References

  1. 1.

    Chédin, F. Trends Genet. 32, 828–838 (2016).

  2. 2.

    Skourti-Stathaki, K. & Proudfoot, N. J. Genes Dev. 28, 1384–1396 (2014).

  3. 3.

    Aguilera, A. & Garcia-Muse, T. Mol. Cell 46, 115–124 (2012).

  4. 4.

    Hamperl, S. & Cimprich, K. A. DNA Rep. 19, 84–94 (2014).

  5. 5.

    Santos-Pereira, J. M. & Aguilera, A. Nat. Rev. Genet. 16, 583–597 (2015).

  6. 6.

    Xu, W. et al. Nat. Plants http://dx.doi.org/10.1038/s41477-017-0004-x (2017).

  7. 7.

    Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I. & Chédin, F. Mol. Cell 45, 814–825 (2012).

  8. 8.

    Sanz, L. A. et al. Mol. Cell 63, 167–178 (2016).

  9. 9.

    Wahba, L., Costantino, L., Tan, F. J., Zimmer, A. & Koshland, D. Genes Dev. 30, 1327–1338 (2016).

  10. 10.

    Huppert, J. L. Mol. Biosyst. 4, 686–691 (2008).

  11. 11.

    Wendte, J. M. & Pikaard, C. S. Biochim. Biophys. Acta 1860, 140–148 (2017).

  12. 12.

    Pikaard, C. S., Haag, J. R., Pontes, O. M., Blevins, T. & Cocklin, R. Cold Spring Harb. Symp. Quant. Biol. 77, 205–212 (2012).

  13. 13.

    Boque-Sastre, R. et al. Proc. Natl Acad. Sci. USA 112, 5785–5790 (2015).

  14. 14.

    Chan, Y. A. et al. PLoS Genet. 10, e1004288 (2014).

  15. 15.

    Whittaker, C. & Dean, C. Annu. Rev. Cell Dev. Biol. http://doi.org/cbp5 (2017).

  16. 16.

    Sun, Q., Csorba, T., Skourti-Stathaki, K., Proudfoot, N. J. & Dean, C. Science 340, 619–621 (2013).

  17. 17.

    Shafiq, S. et al. Mol. Plant 10, 821–833 (2017).

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Correspondence to Frédéric Chédin.

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Chédin, F. Hybrids in the chromatin. Nature Plants 3, 692–693 (2017). https://doi.org/10.1038/s41477-017-0011-y

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