Fig. 4: TF regulatory gene networks provide biological and clinical insights into MM disease. | Nature Communications

Fig. 4: TF regulatory gene networks provide biological and clinical insights into MM disease.

From: Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma

Fig. 4

a TF regulatory gene networks per myeloma subgroup and normal donor PC, as inferred from footprinting analysis. TF are weighed by relative TF binding frequency (colour) and expression (node size). b Heatmap of ranked expression of CXXC1, BPTF, MAZ, KLF13, CBFB and RFX5 across >1000 human cancer cell lines (CCLE dataset). Multiple myeloma cell lines are highlighted in red. Bar plot depicts the number of cell lines per cancer group. c MM patient stratification based on CXXC1, BPTF, MAZ, KLF13, CBFB and RFX5 expression (red, high; blue, low) and analysis of overall survival using the Multiple Myeloma Arkansas (n = 414) and the MMRF Compass Dataset (n = 745). HR hazard ratio.

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