a Top panel, bright field light microscopy of low-risk UM cells (92.1) upon long-term DMSO and PRT-treatment. Bottom panel, DAPI staining of low-risk UM cells (92.1) after 48 h of PRT, and DMSO treatment. Images representative of experimental triplicates. b Violin plots showing the distribution of nuclei size in low-risk UM cells (92.1) upon PRT (n = 152) and DMSO (n = 163) treatment for 48 h. Lines distinguish interquartile ranges; width reflects observed nuclei number. Statistical significance tested using two-sided unpaired Student’s t test, p = 4.9 e−36. Source data are provided as a Source Data file.