Fig. 4: Morphological changes and nuclear enlargement induced by PRC1 inhibition. | Nature Communications

Fig. 4: Morphological changes and nuclear enlargement induced by PRC1 inhibition.

From: Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Fig. 4

a Top panel, bright field light microscopy of low-risk UM cells (92.1) upon long-term DMSO and PRT-treatment. Bottom panel, DAPI staining of low-risk UM cells (92.1) after 48 h of PRT, and DMSO treatment. Images representative of experimental triplicates. b Violin plots showing the distribution of nuclei size in low-risk UM cells (92.1) upon PRT (n = 152) and DMSO (n = 163) treatment for 48 h. Lines distinguish interquartile ranges; width reflects observed nuclei number. Statistical significance tested using two-sided unpaired Student’s t test, p = 4.9 e−36. Source data are provided as a Source Data file.

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