Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV

Health systems have improved their abilities to identify, diagnose, treat and, increasingly, achieve viral suppression among people living with HIV (PLHIV). Despite these advances, a higher burden of multimorbidity and poorer health-related quality of life are reported by many PLHIV in comparison to people without HIV. Stigma and discrimination further exacerbate these poor outcomes. A global multidisciplinary group of HIV experts developed a consensus statement identifying key issues that health systems must address in order to move beyond the HIV field’s longtime emphasis on viral suppression to instead deliver integrated, person-centered healthcare for PLHIV throughout their lives.

Factors negatively affecting the HRQoL of PLHIV include multimorbidity, drug and alcohol dependence, poverty, social isolation, difficulties disclosing HIV status, and persecution due to discriminatory laws and attitudes [7][8][9][10][11][12][13][14] . HIV-related stigma and discrimination negatively affect the HRQoL of PLHIV through multiple pathways, including social rejection, low self-esteem, and barriers to accessing health and support services [15][16][17] . These problems call for a broad health system response to the healthrelated needs of PLHIV. This includes the provision of integrated services for the prevention and management of communicable and non-communicable diseases, along with psychosocial and other support to address common psychological, social, and access challenges. Approaching the healthcare of PLHIV holistically, with decision-making driven by the person's priorities rather than by a pathogen-specific paradigm, has the potential to yield better overall health outcomes 18 . Comprehensive, multidisciplinary healthcare for PLHIV requires an integrated, personcentered approach. This is likely to enhance HRQoL and contribute to improvements in population-level health across all domains, including infectious and noncommunicable diseases, mental health, and sexual and reproductive health.
Achieving consistent, long-term virological suppression has become a key marker of successful HIV care 19,20 . Whilst access to effective ART for all remains essential, it should be seen as one aspect of a more multifaceted definition of success. The central goal should be integrated, person-centered healthcare that promotes the importance of HRQoL, recognizing the right of all people to enjoy "the highest attainable standard of physical and mental health" 21 . The World Health Organization (WHO) Global health sector strategy on HIV 2016-2021 briefly addresses the non-HIV-specific chronic care needs of PLHIV although without mention of HRQoL 22 . UNAIDS has included a general health target for PLHIV in its strategic guidance for the first time in 2021. It calls for 90% of PLHIV to "have access to integrated or linked services for HIV treatment and cardiovascular diseases, cervical cancer, mental health, diabetes diagnosis and treatment, education on healthy lifestyle counseling, smoking cessation advice and physical exercise" 23 . Recently, national and regional initiatives have promoted a more person-centered HIV care agenda 24,25 . This reflects the global movement towards personcentered care for illness in general. A body of evidence, including studies of PLHIV, exists to underpin the concept and practice, which is largely, but not exclusively, from high-income coutries 26 . Person-centered healthcare must value the social networks of patients, promote quality of life, and reform structurally to improve patients' experience interacting with the healthcare system, including respect for and protection of human rights. However, there is not yet a common understanding of what the core values and practices of person-centered, holistic care for PLHIV should encompass, or how aspects of this issue may be context-specific.
As a first step in achieving a common understanding, a multidisciplinary expert panel was convened to engage in a Delphi process to develop a consensus statement on the role of health systems in advancing the long-term well-being of PLHIV from a patient-centered perspective. The overarching purpose of the consensus statement is to guide global, regional, national, and subnational stakeholders in improving health system responses to achieve the best possible long-term health outcomes for PLHIV, including HRQoL outcomes. This article reports on the consensus development process and the agreed-upon consensus points.
Methodology. We employed a standard six-stage Delphi process 27,28 , including the definition of the problem and identification of experts (Stages 1 and 2, concurrently), three survey rounds (Stages [3][4][5], and actions based on the findings (i.e., endorsement of consensus statements and recommendations; Stage 6) 29 . (Further details of the methodology for this Delphi study are presented in the Supplementary Information.) The research team (J.V.L., K.S.) established an expert panel comprised of 44 individuals with expertise in the long-term health needs of PLHIV. The expert panel encompassed diverse disciplinary and geographical perspectives, as well as wide-ranging lived experiences (Table 1, Table 2). Eleven expert panel members, including two people living openly with HIV, served as members of a steering committee that was tasked with providing conceptual guidance for this project (J.A., R.B.L.*, G.B., G.C., N.D.*, M.J.F., R.H., A.K.*, J.V.L.*, C.S., K.S.) (project co-chairs denoted by *). Three teams of steering committee members led scoping reviews of the literature on multimorbidity (G.B., A.K.), HRQoL (M.J.F., R.H.), and stigma and discrimination (J.A., G.C.) in order to identify priority issues to consider for the consensus statement. Specifically, the main findings from the respective reviews guided decision-making regarding potential consensus points. In particular, issues thought to be difficult to address or inadequately addressed (e.g., measurement of health-related quality of life, approaches to addressing stigma) were deemed important by the steering committee and expert panel members alike to include in the consensus process.
The research team drew on health system-related issues identified in the scoping reviews to develop an initial set of 29 proposed consensus points with input from steering committee members. Expert panel members were then asked to indicate agreement or disagreement with consensus points in three survey rounds using the Delphi methodology, with further input collected via qualitative comments on each draft point. In addition, their views were sought on selected topics at an online meeting between the second and third survey rounds.

Results
Overall, agreement consistently increased for the consensus points across survey rounds, which is likely indicative of the incorporation of modifications based on the open-ended comments into the final two rounds. In the third survey round, expert panel members reported unanimous agreement with 22 of the 31 items, and greater than 90% agreement with the remaining nine items (Table 3). In only three of the final 31 points did we observe a somewhat different pattern: point 2.4 had a slight shift from 'Agree' to 'Somewhat agree'; point 4.1 had slight shifts from 'Agree' and 'Disagree' to 'Somewhat agree'; and point 1.3 had a slight shift from 'Agree' to 'Disagree.' For these three points, however, the aggregate ratings were still strongly in agreement. (See the Supplementary Information for an explanation of the consensus grading rubric employed.) Key terms used in the consensus statement are described in Box 1. HIV organizations globally were invited to endorse the final consensus statement (Box 2).

Summary of evidence
Multimorbidity. PLHIV worldwide have a greater burden of multimorbidity than people without HIV and this burden increases with age 3,30-32 . Common comorbidities include hepatitis B, hepatitis C, tuberculosis, and aging-associated noncommunicable diseases such as cardiovascular disease, chronic kidney disease, osteoporosis, and cervical, anal, and other cancers [33][34][35][36][37] . Even with access to effective ART, PLHIV are more likely than people without HIV to experience depression and other mental health disorders, including substance use disorders 16 . Irrespective of whether these conditions precede the HIV infection, which may affect prevention and treatment, multimorbidity in PLHIV is associated with higher levels of hospitalization 38 , higher healthcare costs 39 , higher levels of polypharmacy 40 , and lower HRQoL 7,13 .
Factors contributing to the higher multimorbidity burden in PLHIV include late diagnosis of HIV, ART toxicities, and longterm effects of HIV on the immune system 41,42 . Even among PLHIV who achieve long-term viral suppression, chronic immune activation may contribute to the onset of agingrelated comorbidities 43,44 . Determinants of health, including social determinants such as poverty, stigma, and discrimination, as well as environmental factors such as criminalization and incarceration put some PLHIV at increased risk of developing comorbidities and having poorer comorbidity outcomes 13,[45][46][47] . Health-related behaviors such as smoking and dependent drug or alcohol use further add to the multimorbidity burden 48 . Difficulty in disclosing a positive HIV status, as well as experiences of stigma and discrimination deeply affect the mental health of PLHIV and introduce barriers to engagement in care, hence increasing the risk of poor health outcomes 15,49 . Disease-specific approaches to the provision of health services for PLHIV are likely to be inefficient, particularly because it is common for multiple comorbidities to share the same risk factors, resulting in syndemics 50 . Integrated healthcare models tailored to reflect the multimorbidity-related needs of PLHIV in different geographical settings have the potential to deliver better health outcomes, if implemented equitably 51 , and can do so costeffectively 52 . By addressing the prevention, screening, and management of comorbidities in a person-centered manner, guided by the needs of individual patients, health systems can also respond flexibly to the multidimensional process of aging with HIV, taking into account both chronic and episodic healthrelated needs 53 . The priorities of PLHIV may differ from those of service providers. For example, PLHIV may be more concerned than providers about issues such as pain and sleep disturbance 54 . Addressing concerns identified by PLHIV will be important for effective treatment and symptom management.
A new paradigm is needed for addressing multimorbidity in PLHIV. The conceptualization of frailty in geriatric healthcare suggests a framework for identifying PLHIV who are at higher risk of poor health outcomes 55 . WHO's conceptualization of healthy aging as a process that is influenced by both intrinsic capacity and the environment may also provide insights, along with the related concept of functional ability, which emphasizes people's ability to do what is important to them at different stages of their lives 55,56 . Further research is needed to determine how these approaches can inform the clinical care of PLHIV.
Health-related quality of life. Health is defined by WHO as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity" 57 , while international law recognizes the human right of all persons to "enjoyment of the highest attainable standard of physical and mental health" and requires States to take measures to progressively realize this right over time 58 . HRQoL is increasingly acknowledged as an important aspect of health. It is commonly assessed by patientreported outcome measures (PROMs), which reflect people's subjective perceptions of their health-related experiences 59 . Validated PROMs can be used to systematically quantify people's HRQoL, allowing for observations about how HRQoL varies among individuals, across groups, and over time. The comprehensive multidimensional nature of PROMs that measure HRQoL makes them a useful tool for determining how well people are responding to the challenges associated with complex chronic health conditions. Incorporating HRQoL monitoring into clinical and community services for PLHIV can provide a personcentered perspective on the effectiveness of interventions, inform health-related decision-making, and identify PLHIV who would benefit from clinical and community services to address modifiable factors that negatively affect HRQoL.
The relevance of HRQoL as a measure of well-being among PLHIV is well-established. PLHIV have reported poorer HRQoL when compared to members of the general population, and also poorer HRQoL than people with other chronic health conditions [3][4][5] . Poorer HRQoL scores are closely correlated with worse clinical health measures such as low CD4 T-cell count and the occurrence of AIDS-defining events [60][61][62][63] . While comorbidities, disability, and pain impair HRQoL 7,64-66 , successful HIV treatment has a positive impact 67,68 . Physical and mental dimensions of HRQoL scores predict viral rebound and all-cause hospitalization 69 . Better scores on the physical dimension of HRQoL predict survival among PLHIV receiving ART, as well as emergency department utilization and hospital discharge rates 70,71 . Enhancing HRQoL has the potential to improve clinical outcomes, adherence, and retention in care 7,60 .
PLHIV report a number of components of HRQoL that are important to them. These include physical (e.g., pain and gastrointestinal issues), cognitive (e.g., memory and sleep), psychological (e.g., anxiety and depression), social (e.g., isolation and intimacy), functional (e.g., independence and ability to perform everyday activities), welfare (e.g., finances and fears regarding immigration status), spiritual well-being (e.g., achieving a sense of peace), and information (e.g., about long-term outcomes about their condition) components [72][73][74] . However, issues that are important to PLHIV, especially nonphysical issues, maybe missed by those providing routine clinical care due to existing service delivery structures and a lack of training about and awareness of these issues 75 . A healthcare approach that focuses solely or primarily on laboratory results may lead PLHIV to feel that the physical and psychosocial concerns that matter to them are not equally important to their healthcare providers 76 . Therefore, validated PROMs used to measure HRQoL should reflect the symptoms and concerns reported by PLHIV and should be culturally appropriate, including for marginalized groups. Several internationally validated instruments, generic and HIV-specific, are currently used to measure HRQoL in PLHIV for general population comparisons, medico-economic assessments, and specific research and clinical purposes (e.g., SF-12v2, MOS-HIV, PROQOL-HIV, WHOQOL-bref) 59 . As both internalized and enacted stigma negatively impact HRQoL 77,78 , some validated instruments, such as PROQOL-HIV 79 , have included a sub-scale measuring stigma as a component of HRQoL.
Potential benefits of using PROMs in routine HIV care have been readily identified by PLHIV and their service providers: achieving a person-centered approach, empowering individuals to raise concerns, feeling that all concerns are heard and taken seriously, facilitating discussion of sensitive problems, increasing engagement with services and treatment adherence, and identifying who is benefiting or not benefiting from care and support strategies 47 .
HIV-related stigma and discrimination. PLHIV may experience multiple forms of stigma and discrimination at various levels (e.g., policy and law, health system, and interpersonal) and in different  settings (e.g., health sector, education, workplace, the justice system, families and communities, and emergency and humanitarian settings) 80 . Such experiences have direct social and health consequences (e.g., depression, anxiety, substance use, impaired quality of life, social exclusion, internalized stigma) 16 . They also adversely affect decisions regarding prevention behaviors, engagement in care, and uptake of social services [81][82][83][84] . Discriminatory laws that criminalize or otherwise punish key populations, or that prohibit or impede the delivery of specific health services (e.g., affordable medications, harm reduction services, drug dependence treatment, and sexual and reproductive healthcare), or that fail to respect and protect human rights such as privacy or autonomy in medical decisionmaking, constitute major barriers to the successful implementation of models for comprehensive care for PLHIV 85 . Legal and policy frameworks also can harm the material well-being of PLHIV when social security programs do not adequately support those experiencing disability related to HIV or comorbidities, or when HIV or comorbidity services are not reimbursed, resulting in catastrophic health expenditure 86 .
These examples underscore the role of HIV-related stigma as a major driver of health inequities 87 . The stigma associated with real or perceived HIV status, including within healthcare settings, also intersects with other forms of stigma and discrimination related to social identities or characteristics, e.g., race, ethnicity, sexual orientation, gender identity, age, disability, poverty, migrant status, sex work, drug use, and prior or current incarceration 15,88 . This intersectional stigma can adversely affect physical and mental health outcomes 15 . Layered stigma intensifies the intertwined stigma-discrimination-care relationship, which may lead to delayed, sub-optimal, or avoided care 81,82 . The overload caused by suffering intersectional stigmas has adverse effects on both mental health and health behaviors. This means that the health, economic, and social needs of PLHIV suffering structural inequality must be viewed through the prism of intersectionality if there is to be a reduction in the cognitive, social, physical, and moral distancing these groups experience from that of other people 89 .
Examples of stigma and discrimination reported by PLHIV in healthcare settings include excessive infection control precautions taken by providers, longer waiting times, disrespect, negligence, reduced confidentiality, delay or denial of treatment, and poor support services 90 . Two mechanisms act in synergy: reduced care-seeking behaviors for fear of experiencing stigma and discrimination, and the stigmatizing and discriminatory actions of healthcare staff. Secondary stigma, arising from providing care to stigmatized groups, can also affect health providers and modify their attitudes 90 . PLHIV with multimorbidity may be treated in services where HIVrelated stigma could be compounded by additional stigma associated with specific comorbidities (e.g., depression or liver cancer 84 ) or through lack of experience with PLHIV. Specific integrated or shared care models incorporating specialists in HIV and other staff, and the development of HIV-friendly practices, are promising approaches to providing personcentered, continuous care 91,92 .  Given the pervasiveness of stigma and discrimination directed at PLHIV in healthcare settings, it is crucial to monitor this experience using validated measures. HRQoL instruments including a stigma dimension (e.g., PROQoL) 79 may provide an option for data collection of routine patient-reported outcomes. Some validated instruments, such as the People Living with HIV Stigma Index 2.0 93 and the HIV Stigma Scale 94 , which have been validated in various settings around the world with support from PLHIV, monitor longitudinal trends of experienced stigma 59 . These could be complemented with measures of stigma expressed by healthcare providers [95][96][97][98] .
Interventions to counter HIV-associated stigma should also be implemented 99,100 .
Such interventions have been evaluated 15,101-103 and can be categorized as: information-based, structural, biomedical, skill-building, empowerment-based, and contact-centered 98 . Interventions may be patient-focused or provider-focused, and it is possible that optimal impact may be achieved when combinations of interventions are employed. However, further evidence on the effectiveness of such interventions is needed. At a minimum, all types of healthcare settings should provide PLHIV with information about their human rights and a channel for reporting behaviors and policies that are discriminatory or otherwise infringe upon rights in this setting.

Discussion
While continuing to press for the crucial goal of equitable universal access to ART, health systems must also expand the focus of HIV care. This broader approach will enable PLHIV to experience optimal long-term well-being, consistent with the realization of the human right to enjoy the highest attainable standard of physical and mental health. With this goal in mind, the multidisciplinary expert panel developed this consensus statement on the role of health systems in advancing the longterm well-being of PLHIV. The process resulted in 31 items with which expert panel members expressed high levels of agreement. The consensus statement reflects the current state of knowledge about health-related challenges for PLHIV in the key domains of multimorbidity, HRQoL, and stigma and discrimination, as well as addressing psychosocial needs associated with these issues. Proposed measures for improving the long-term health outcomes of PLHIV build on key principles in the fields of HIV and global health, including principles expressed in the Constitution of the World Health Organization 57 , the 2030 Agenda for Sustainable Development 104 , the United Nations Political Declaration on Universal Health Coverage 105 , and the WHO Framework on Integrated, People-Centered Health Services 106 . This consensus statement and the associated recommendations for action have

Box 1 | Key concepts
Health-related quality of life (HRQoL)-a construct that reflects an individual's perceptions of his or her well-being in health-related aspects of life, with the concept of health understood to encompass physical, mental, and social dimensions 123,124 . While there is a lack of consensus regarding how HRQoL should be defined, instruments that measure HRQoL commonly address multiple aspects of physical, mental, and social well-being, such as mobility, pain, anxiety, depression, social functioning, and vitality 124 .
Health system-as defined by the World Health Organization, "all organizations, people and actions whose primary intent is to promote, restore or maintain health…. A health system is, therefore, more than the pyramid of publicly owned facilities that deliver personal health services. It includes, for example, a mother caring for a sick child at home; private providers; behavior change programmes; vector-control campaigns; health insurance organizations; occupational health and safety legislation 125 ." HIV-related discrimination-as defined by UNAIDS, "the unfair and unjust treatment (act or omission) of an individual based on his or her real or perceived HIV status. Discrimination in the context of HIV also includes the unfair treatment of other key populations, such as sex workers, people who inject drugs, men who have sex with men, transgender people, people in prisons and other closed settings and, in some social contexts, women, young people, migrants, refugees, and internally displaced people…. Discrimination can be institutionalized through existing laws, policies and practices that negatively focus on people living with HIV and marginalized groups, including criminalized populations 99 ." HIV-related stigma-as defined by UNAIDS, "the negative beliefs, feelings, and attitudes towards people living with HIV, groups associated with people living with HIV (e.g., the families of people living with HIV) and other key populations at higher risk of HIV infection, such as people who inject drugs, sex workers, men who have sex with men and transgender people 99 ." Integrated health services-as defined by the World Health Organization, "health services that are managed and delivered so that people receive a continuum of health promotion, disease prevention, diagnosis, treatment, disease-management, rehabilitation, and palliative care services, coordinated across the different levels and sites of care within and beyond the health sector, and according to their needs throughout their life course 126 ." Internalized stigma-an "individual's personal acceptance" of the stigma associated with their stigmatized identity 127 . Intersectional stigma and discrimination-a concept "characterize[d by] the convergence of multiple stigmatized identities within a person or group 128 " and discussed by the UNAIDS Global Partnership for Action to Eliminate All Forms of HIV-related Stigma and Discrimination as, "fueled by multiple factors, including their HIV or another health status, age, sex, gender identity, sexual orientation, race, disability, ethnicity, drug use, migration status, etc 80 ." Key populations-as defined by the World Health Organization, "groups who, due to specific higher-risk behaviors, are at increased risk of HIV irrespective of the epidemic type or local context. Also, they often have legal and social issues related to their behaviors that increase their vulnerability to HIV." The five key populations widely addressed in the global response to HIV are men who have sex with men; people who inject drugs; people in prisons and other closed settings; sex workers; and transgender people 129 . Multimorbidity-the coexistence of multiple (somatic and/or mental) health conditions in addition to HIV. People-centered care-as defined by the World Health Organization, "an approach to care that consciously adopts individuals', carers', families' and communities' perspectives as participants, and beneficiaries of, trusted health systems that are organized around the comprehensive needs of people rather than individual diseases, and respects social preferences. People-centered care also requires that patients have the education and support they need to make decisions and participate in their own care and that carers are able to attain maximal function within a supportive working environment. People-centered care is broader than patient and person-centered care, encompassing not only clinical encounters but also including attention to the health of people in their communities and their crucial role in shaping health policy and health services 126 ." Psychosocial health services-As defined by the US Institute of Medicine, "psychological and social services and interventions that enable patients, their families, and health care providers to optimize biomedical health care and to manage the psychological/behavioral and social aspects of illness and its consequences so as to promote better health 130 ." Vulnerable populations-As defined by the World Health Organization, "groups of people who are particularly vulnerable to HIV infection in certain situations or contexts, such as adolescents (particularly adolescent girls in sub-Saharan Africa), orphans, street children, people with disabilities and migrant and mobile workers. These populations are not affected by HIV uniformly across all countries and epidemics 129  West Africa the potential to improve the well-being of PLHIV throughout their lives. It has long been recognized that respecting, protecting, and fulfilling human rights can yield better health outcomes for PLHIV 49 , yet human rights are contested in ways that undermine many aspects of the HIV response worldwide. As health systems focus more on the long-term care needs of PLHIV, it is imperative to address the human rights challenges that undermine this effort. Discrimination against PLHIV in healthcare settings is one of many such issues that warrant urgent attention 80 . While some matters are determined by actors outside of health system institutions (e.g., lawmakers adopting laws that regulate certain aspects of how health systems operate and how services are delivered), it is within the power and purview of health system actors (institutions and individuals) to influence many structural factors so as to reduce discrimination and other barriers. Therefore, health systems and the people who work within them must recognize and work to eliminate the multiple forms of structural discrimination that undermine the health of PLHIV. They have an important vantage point as observers of the consequences of such barriers for health and HRQoL and an influential position as advocates, with considerable moral and political persuasion. They also bear responsibility for removing such barriers within healthcare settings, for example by promoting initiatives to hire diverse and inclusive workforces, establishing systems to report and investigate discrimination, and providing health services in geographical locations and at times that will facilitate access for marginalized or vulnerable populations. A pervasive and highly problematic form of structural discrimination is HIV criminalization (i.e., the unjust application of criminal law to people living with HIV based solely on their HIV status), alongside the criminalization and stigmatization of various activities associated with HIV risk 107 . Other relevant and pressing human rights issues include privacy and confidentiality, personal autonomy, access to justice, and meaningful participation in health decisionmaking 108 .
Meaningful participation can be advanced by including PLHIV in the development and enactment of policy and programmatic responses, as called for by the widely endorsed Greater Involvement of People Living with HIV Principle 109 . PLHIV have unique insight into the factors that positively and negatively affect their well-being. Their perspectives are essential in the formulation of effective strategies both at the policy and the service delivery levels 110 . The 2021 United Nations Political Declaration on HIV and AIDS called for the expansion of community-led HIV service delivery to comprise at least 30% of testing and treatment-related services by 2025 111 . This target is even more important in the context of improving the long-term health-related outcomes of PLHIV. Community-based health and psychosocial service providers can do more than supplement government and private services; they also are well-suited to identify innovative and costeffective models of care and to engage marginalized and vulnerable populations 19,110 . Efforts to address the needs of PLHIV in relation to multimorbidity, HRQoL, and stigma and discrimination can be greatly enhanced through the involvement of communities in setting the research and programmatic agendas, as well as in direct service delivery; such activities need to be sustainably supported and financed.
Evidence suggests that living long-term with HIV can bring episodic functional concerns 112 . Continuous assessment in routine care is essential for anticipation, detection, and management of fluctuating concerns. Such care should include HRQoL measures that take a multidimensional approach, reflecting what matters to PLHIV, including concerns such as stigma and social function 72,113 . For self-reported HRQoL outcomes to inform care delivery in a more person-centered manner, health systems and service organizations must pay careful attention to language, culture, and local and individual priorities regarding well-being. Data should be collected and used within a meaningful patientprovider relationship in order to optimize validity and reliability 114 . This has been achieved even in resource-limited settings with poor literacy and advanced HIV infection 115 . Locally developed systems in Africa, for example, have enabled patients to self-report using a "hand-scoring" system 116 . Other systems support community caregivers of people with cancer and HIV in India and African countries to collect self-reported patient outcomes using mHealth, providing data directly to a provider "dashboard" to inform the allocation of staff resources to those most in need 117 . A growing body of evidence indicates that service delivery approaches to HIV care can incorporate attention to patient experiences and concerns in high-prevalence, lowresource areas 85,118 .
The expert panel carried out its work with the understanding that health systems vary substantially across, and often within, countries. Patterns of multimorbidity likewise vary greatly across geographical regions. Monitoring progress in the global HIV response requires a set of standardized indicators of health behaviors and comorbidities that contribute substantially to the global multimorbidity burden 119 . To the extent that resources allow, health systems are strongly encouraged to monitor these behaviors and comorbidities and to solicit input from PLHIV on additional national monitoring priorities 1,120 . Although many national health systems are not currently monitoring HRQoL, stigma, or discrimination among PLHIV, they should, at a minimum, include indicators from the UNAIDS Global AIDS Strategy 2021-2026, in order to standardize monitoring.
In its Global AIDS Strategy, UNAIDS set ambitious 2025 targets. It established 10 result areas that broadly aim to achieve equitable access to fully-resourced and integrated HIV services for all people living with or at risk of HIV. Priority actions, which support the targets and result areas, are generally aimed at national governments, though nearly all require support from non-government stakeholders. While priority actions may vary by geographic region, even in the context of limited resources, our consensus statement offers concrete recommendations regarding multimorbidity, HRQoL, and stigma and discrimination that all health systems should aspire to implement. The consensus points and next steps (Box 3) articulate the direction in which healthcare for PLHIV should evolve in all countries, emphasising that a reorientation of health systems will necessarily be incremental. The expert panel also recognises that the evidence base underpinning its conclusions is limited in some ways but rapidly growing. Thus the consensus statement should be regarded as an initial articulation of a transformational process, to be refined as stakeholders in government, civil society, research, healthcare and the social and legal sectors deepen their understanding of how health systems can support PLHIV in achieving optimal wellbeing.
Across the three Delphi rounds, three consensus points (2.4, 4.1, and 4.4) generated lower overall agreement than the others. This was reflected in our decision to continue to evaluate them on a four-point Likert scale in the third Delphi round instead of the binary agree/disagree measurement used with the other points. The results from that round revealed a continued, relatively lower level of agreement for two of the statements (2.4 and 4.1) ( Table 3). The lack of unanimity here may highlight a lack of consensus among different types of stakeholders in the broader HIV field regarding whether some issues (e.g., pain) should be prioritized in health system efforts to improve health outcomes for PLHIV. It may also reflect the lack of shared conceptual frameworks for other issues such as stigma and discrimination, punitive laws, and intersectionality, pointing to a possible need to engage a wider range of stakeholders in dialog about these issues.
Limitations and strengths. The Delphi process involving a virtual expert panel enables the systematic gathering of the collective knowledge and recommendations of leaders in the field while separated by physical distances 27,121 . However, this process has both limitations and strengths. Typical of the Delphi method, the research team used purposive sampling to recruit potential expert panel members from existing HIV networks. The initial roster was then expanded using snowball sampling to include a wider range of experts and, potentially, viewpoints. The use of English in conducting the study may have restricted the composition of the expert panel and, by extension, the study outputs. The size of Delphi panels can range widely. This study included 44 individuals, which is within the 10 to 50 generally recommended for expert panels 122 . Members were from 22 countries across the six WHO regions. We note that 25% of them worked in a country different from their country of origin and speculate that their assessment of consensus points may have benefitted from their diverse backgrounds. However, this also meant that in the case of Africa, with its disproportionate burden of HIV, two of the six African members no longer worked on the continent. Thus, it is not clear to what extent they considered the African context in their assessment of consensus points. That the composition of the panel reflected activities spanning research, service provision, community-based care, policy, and advocacy provided the project with expertise and knowledge regarding the priorities of diverse stakeholder groups.
An advantage of using scoping reviews for the three domains is that expert panel members could draw on their knowledge and experience to focus on issues that pertain to improving the wellbeing of PLHIV but may not yet be extensively documented in the peer-reviewed or gray literature. A further strength of the study was the collection of open-ended (text-based) comments from respondents who agreed with statements (e.g., for further input and suggested edits), as well as from respondents who disagreed (e.g., to understand their rationale and suggested changes). This elicitation and incorporation of feedback from respondents across all three survey rounds (with high response rates, i.e., R1, R2 = 86%; R3 = 91%) and the online meeting were likely critical to the consistent increase in levels of agreement.
Finally, the worldwide relevance of the expert panel's consensus is suggested by the fact that the consensus statement had been endorsed by 67 organizations (Box 2) at the time this article went to press.

Conclusion
Prevention and treatment of HIV infection including access to ART remain a major public health and human rights challenge that requires urgent, sustained attention. This consensus statement addresses the concurrent role of health systems in advancing the long-term well-being of PLHIV. Multimorbidity, HRQoL, and stigma and discrimination continue to be major issues for PLHIV, including those who have achieved viral suppression and in particular those from marginalized populations.
The consensus statement was prepared by a large multidisciplinary panel of experts representing the interests of a diverse range of stakeholders including HIV community members. Its purpose was to facilitate consensus on major health-related issues affecting PLHIV to be addressed from a patient-centered perspective, noting that many issues are not captured in current HIV monitoring processes and guidelines. While additional research is needed, the burden of creating new, simple, standardized indicators for insufficiently addressed issues will largely fall on international bodies such as WHO and UNAIDS, both of which have mechanisms for community consultation and engagement. This process will require a strong commitment from all Member States, which must report on the indicators and implement policies to enhance health system performance. We encourage these organizations and national health system monitoring bodies to continue to take on this task, to report at regular intervals, and to meaningfully involve PLHIV, even when additional costs are involved. PLHIV and civil society organizations should also play a role in reporting ways in which governments are not meeting their obligations. Ultimately, a concerted effort by all stakeholders is required to ensure the long-term well-being of the millions of people around the world living with HIV and to end the HIV pandemic.