Fig. 6: CDKN1C mRNA expression is linked to chromatin accessibility of CERES and GR levels in clinical samples. | Nature Communications

Fig. 6: CDKN1C mRNA expression is linked to chromatin accessibility of CERES and GR levels in clinical samples.

From: Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

Fig. 6

a Biopsies of human primary non-lymphoid solid cancers were subjected to whole-transcriptome and chromatin accessibility analysis by the TCGA (n = 404). b (top) Representative samples showing chromatin accessibility signal at CERES enhancer. b (bottom) Expression of CDKN1C, MKI67, PCNA, and FOXM1 sorted based on CERES accessibility. Survival events (alive = white, dead = green), SWI/SNF mutation status (WT = white, mutated = green), and cancer types are displayed below. c Histogram depicting correlation value counts for CDKN1C expression levels and 306 up- and downstream enhancers in its genomic vicinity. Red line shows the correlation of CERES accessibility with CDKN1C expression. d Histograms showing correlation of four proximal genes with the accessibility of 306 up- and downstream enhancers surrounding CDKN1C. Red lines show correlations of these genes with CERES accessibility. e Line plot showing Spearman’s correlation of accessibility of CERES (red) or 306 (blue) surrounding enhancers with CDKN1C mRNA levels, and NR3C1 mRNA levels (green).

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