a Relative IL-25 mRNA levels in the intestinal epithelium of naïve mice, mice infected with Tm or Nb, and succinate-treated mice. b–d Administering rIL-25 restored the type 2 immune response in Lrmp−/− mice. The expansion of tuft and goblet cells (b), the population of eosinophils and ILC2s (c), and relative IL-13 mRNA levels (d) were examined after administering rIL-25 (0.5 µg/day; i.p.) for 7 days in Lrmp+/+ and Lrmp−/− mice. e rIL-25 promoted Nb clearance in p53−/− and Lrmp−/− mice. Mice were infected with Nb at day 0 and treated with rIL-25 every 2 days. Egg counts (left) and intestinal worm burden (right) were quantified at 7 d.p.i. f Schematic illustration of the role of p53-Lrmp signaling in the intestinal type 2 immunity towards parasitic infections. Data are presented as mean ± SEM. Each dot represents a mouse. n = 5–8/group. *p < 0.05; **p < 0.01; ***p < 0.001; NS: non-significant, two-tailed Student’s t-test.