Fig. 6: rIL-25 administration restores the type 2 immune response in Lrmp−/− mice and rescues the impaired ability to expel Nb in p53−/− and Lrmp−/− mice. | Nature Communications

Fig. 6: rIL-25 administration restores the type 2 immune response in Lrmp−/− mice and rescues the impaired ability to expel Nb in p53−/− and Lrmp−/− mice.

From: Tumor suppressor p53 regulates intestinal type 2 immunity

Fig. 6

a Relative IL-25 mRNA levels in the intestinal epithelium of naïve mice, mice infected with Tm or Nb, and succinate-treated mice. bd Administering rIL-25 restored the type 2 immune response in Lrmp−/− mice. The expansion of tuft and goblet cells (b), the population of eosinophils and ILC2s (c), and relative IL-13 mRNA levels (d) were examined after administering rIL-25 (0.5 µg/day; i.p.) for 7 days in Lrmp+/+ and Lrmp−/− mice. e rIL-25 promoted Nb clearance in p53−/− and Lrmp−/− mice. Mice were infected with Nb at day 0 and treated with rIL-25 every 2 days. Egg counts (left) and intestinal worm burden (right) were quantified at 7 d.p.i. f Schematic illustration of the role of p53-Lrmp signaling in the intestinal type 2 immunity towards parasitic infections. Data are presented as mean ± SEM. Each dot represents a mouse. n = 5–8/group. *p < 0.05; **p < 0.01; ***p < 0.001; NS: non-significant, two-tailed Student’s t-test.

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