Abstract
The construction of 7-membered ring via direct C7–H cyclization of benzoimidazoles with alkenes would provide a more atom- and step-economical route to tricyclic imidazoles and derivatives that widely exist in a broad range of bioactive molecules. However, transition metal-catalyzed C–H cyclization for medium-ring synthesis has been limited to reactive C–H bonds, instead, the activation of unreactive C–H bonds towards medium synthesis still remains an elusive challenge. Herein, we report a direct construction of 7-membered rings via Ni–Al co-catalyzed unreactive C7–H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles in 40–98% yield and with up to 95:5 er.
Similar content being viewed by others
Introduction
Tricyclic imidazoles and derivatives bearing a 7-membered ring are an important class of structural motifs that widely exit in diverse range of bioactive and material molecules (Fig. 1a)1,2,3,4,5,6,7. However, due to the difficulty in construction of medium rings that requires overcoming unfavorable entropy and transannular strain8,9,10, synthetic routes of such tricyclic imidazoles are quite limited. A typical method relies on Friedel-Crafts acylation for cyclization, often requiring multiple synthetic steps and stoichiometric amounts of AlCl3 catalyst (Fig. 1b)11,12,13,14. Another alternative is to use alkene metathesis to form 7-membered rings, generally needing lengthy routes for both starting material preparation and final product formation (Fig. 1c)15. Thereby, direct construction of 7-membered ring via C7–H cyclization of benzoimidazoles with alkenes would provide a more straightforward, atom- and step-economical access to tricyclic imidazoles from more easily-accessible substrates. However, transition metal-catalyzed C–H cyclization for medium-ring synthesis has been a challenging goal during the past two decades16,17. Early efforts focused on the cyclization of reactive formyl C–H bonds with alkenes via rhodium catalysis18,19,20,21,22,23,24,25,26,27,28. Until recent years, non-formyl C–H bonds were also able to be activated via nickel catalysis to form 7-membered rings (Fig. 1d)29,30,31,32,33,34, while these examples were still limited to reactive C–H bonds such as heterocyclic and polyfluoro-aromatic C–H bonds, and moreover, only scattered substrates were reported with in general low to moderate yield and ee. In contrast, the activation of prevalent and unreactive aromatic C–H bonds towards 7-membered ring synthesis still remains an elusive challenge. The difficulty was ascribed to the fact that unreactive aromatic C–H bonds are often more reluctant to be activated by low-valent metals owing to their higher bond strength and weaker acidity35.
a Tricyclic imidazoles bearing a 7-membered ring in bioactive molecules and materials. b Typical method I: Friedel-Crafts reaction. c Typical method II: alkene metathesis reaction. d Medium ring synthesis via transition metal-catalyzed cyclization of reactive C–H bonds. e Ni–Al bimetal-catalyzed direct C7–H cyclization for synthesis of tricyclic imidazoles bearing a 7-membered ring (this work).
Here, we show that the construction of 7-membered ring via Ni–Al bimetal-catalyzed unreactive C7–H bond cyclization of benzoimidazoles with alkenes is achieved, providing a series of tricyclic imidazoles in 40–98% yield and with exclusively endo selectivity and up to 95:5 er (Fig. 1e). In this reaction, the use of Ni–Al bimetallic synergistic catalysis instead of traditional mono-metal catalysis36,37,38,39,40,41,42,43,44,45,46,47 greatly facilitated the formation of medium rings owing to the following two reasons: (1) the coordination of Al-Lewis acid to the N atom of imidazoles would contribute to decreasing electron density of the aromatic ring, thus promoting C–H bond activation; (2) proper steric hindrance from C2 substituent of benzoimidazoles would reduce unfavorable entropy effect, favoring the formation of medium rings.
Results
Reaction optimization
We commenced our study by selecting benzoimidazole 1a as a model substrate, nickel as a catalyst and Al-Lewis acid as a co-catalyst (Fig. 2). A systematic survey on Ni metals, Al Lewis acids, ligands, bases, and other reaction parameters led to the optimal conditions: 10 mol% of Ni(cod)2, 10 mol% of IPr·HCl, 10 mol% of AlMe3 and 40 mol% of tBuOK in toluene at 130 °C, under which an endo cyclization was exclusively achieved, providing tricyclic imidazole 2a bearing a 7-membered ring in 98% yield (entry 1).
Reaction conditions: 1a (0.20 mmol), toluene (1.0 mL), under N2 for 3 h. Yield was determined by 1H NMR analysis with CH2Br2 as the internal standard. IPr = 1,3-bis(2,6-diisopropylphenyl)-2,3-dihydro-1H-imidazole. Cy3P = triisopropylphosphine. dppe = 1,2-bis(diphenylphosphino)ethane. BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene. IMes = 1,3-dimesityl-2,3-dihydro-1H-imidazole. SIPr = 1,3-bis(2,6- diisopropylphenyl)imidazolidine. DME = 1,2-dimethoxyethane.
Control experiments showed that the combination of Ni, IPr, AlMe3 and tBuOK is critical, and the removal of any of them would greatly reduce the yield (entries 2–5). Traditional phosphine ligands such as monophosphines and bidentate phosphines were all ineffective (entries 6 and 7), whereas other N-heterocyclic carbenes were still compatible, albeit with a little lower yields (entries 8 and 9). In addition, in situ formed Ni(0) was also an effective catalyst, yet providing only 42% yield (entry 10). Base acted as another critical role in the reaction. tBuOLi was inefficient, whereas tBuONa worked well, affording a comparable result to that of tBuOK (entries 11 and 12). Notably, more than 10 mol% of tBuOK was essential to the reactivity (entries 13–15). The use of 10 mol% of tBuOK gave no products (entry 13), instead, leading to an imidazole with free NH group in 5% yield, which was formed from the decomposition of alkene-isomerization substrate. We reasoned that excess tBuOK could suppress the isomerization of the terminal alkene as the literature proposed48.
Scope of imidazoles and alkenes
With the optimized conditions in hand, various benzoimidazole motifs bearing different substituents on the aromatic ring were investigated first (Fig. 3). Results showed that either electron-donating groups such as methyl (2b) and tert-butyl (2c) or electron-withdrawing groups such as CF3O (2d), F (2e to 2h), CF3 (2i) and carboxylate (2j) were well compatible with the reaction, providing the corresponding products in 80–98% yield. Notably, C2 substituents of benzoimidazoles proved critical to the reactivity. Without C2 substituents, C2–H cyclization would dominate to form a 6-membered ring as we previously reported41, further suggesting that C7–H bond was quite unreactive towards Ni catalysis. In general, electron-deficient CF3 group on C2 position can ensure high reactivity with using only 10 mol% of AlMe3 co-catalyst, while CF3 group was not indispensable, and it can be replaced by a broad range of other substituents such as alkyl (2k and 2l), (hetero)aryl (2m and 2n), carbamoyl (2o and 2p), alkoxy (2q) and amino (2r) groups, providing the corresponding products in 40–79% yield by tuning the amount of AlMe3. Pleasingly, imidazole-2-ones, which also widely exist in numerous bioactive compounds, were well compatible with the current reaction.
Reaction conditions: 1 (0.20 mmol), toluene (1.0 mL) under N2 for 3 h. Yield of isolated products. *AlMe3 (200 mol%) was used. †AlMe3 (60 mol%) was used. ‡AlMe3 (100 mol%) and tBuOK (80 mol%) were used.
When N-protecting groups varied from Me (2s), Bn (2t), PMP (2u) to Ph (2v), the corresponding products can be smoothly obtained in 64–90% yield. In consideration of two symmetrical N atoms in the molecule, dual C–H annulation was then investigated and a tetracyclic product (2w) bearing two 7-membered rings can be smoothly achieved, which is not easily accessed by traditional Friedel-Crafts reaction because the second acylation would be quite difficult. Besides simple aryl and alkyl groups, carboxylate group was also tolerated, providing a translocator protein inhibitor (2x) in 60% yield1.
Next, the compatibility of alkene motifs were investigated (Fig. 4). Although internal and trisubstituted alkenes were ineffective because of big steric hindrance, various 1,1-disubstituted terminal alkenes proved to be effective. Different types of alkyls such as methyl (3a), linear n-butyl (3b), branched cyclohexyl (3c) and functionalized alkyl (3d) were well tolerated, delivering the corresponding products in 82–96% yield. Considering that the incorporation of aryl motifs can significantly increase the complexity of molecules, we examined various aryl substituted alkenes (3e–3p). Results showed that these aryl alkenes bearing either electron-rich groups such as methyl (3f–3h), tBu (3i), Ph (3j), methoxy (3k), and naphthyl (3l) or electron-deficient groups such as CF3O (3m) and F (3n–3p) at different positions of the aryl ring all proceeded smoothly, providing the corresponding products in 50–90% yield.
Reaction conditions: 1 (0.2 mmol), toluene (1.0 mL) under N2 for 3 h. Yield of isolated products.
Enantioselective attempts
For the synthesis of medium ring, a flexible large ring transition state would be involved, rendering the enantioselective control of such a reaction quite challenging29,30,31,32,33,34. By surveying a wide range of chiral carbenes, we found that bulky ANIPE, previously developed by Shi and Cramer groups49,50,51, was the optimal ligand (see the Supplementary Information for details). With this ligand, a series of substrates with various alkene motifs were then tested (Fig. 5). In general, various aryl groups were well compatible with the current reaction, providing the corresponding products in good yields and with 91.5:8.5 to 95:5 er ((R)-3e to (R)-3q). However, alkyl groups, albeit still with good yields, would result in slightly decreased ee ((R)-3a, (R)-3d, (R)-3r and (R)-3s) owing to bigger structural flexibility. The (R) absolute configuration of major enantiomer of the product was determined by single crystal X-ray diffraction.
Reaction conditions: 1 (0.20 mmol), Ni(cod)2 (10 mol%), ANIPE·HCl (10 mol%), AlMe3 (80 mol%), tBuOK (40 mol%), toluene (1.0 mL) at 130 °C under N2 for 3 h. Yield of isolated products. Ee was determined by chiral HPLC.
Reaction utility and mechanistic discussion
To demonstrate the utility of the current method, a gram-scale reaction of 1a was conducted, and a comparable yield was obtained under the standard conditions (Fig. 6a). Tricyclic imidazole derivative 2s can be easily oxidized at the benzylic position to produce an intermediate 4 in 62% yield, which can be further transformed into various bioactive molecules such as β-2-adrenergic agonists and zilpaterol (Fig. 6b)11,12,13,14. In addition, bioactive molecule, translocator protein inhibitor (2x in Fig. 3), can be easily accessed from readily available imidazole-2-one through the current method.
a Gram-scale reaction. b Product transformation. c Deuterium labeling experiments. d Kinetic isotope effect. e Proposed mechanism.
To gain more insights into the reaction, relevant mechanistic experiments were conducted. Deuterium-labeling experiment showed that C7-D on the aromatic ring was completely transferred to the 7-membered ring, and moreover, no deuterium scrambling was observed at other positions (Fig. 6c), which suggested that an endo-insertion of alkene to Ni–H bond could proceed via an irreversible step. Both competitive experiment between equivalent moles of 1a and d4-1a and parallel reactions revealed significant kinetic isotope effect (kH/kD = 5.75, 4.81, respectively), indicating that the C–H cleavage could be the rate-determining step (Fig. 6d), and it could proceed via oxidative addition mechanism because direct H transfer pathway in general gives low kinetic isotope effect35. In addition, 19F NMR spectra of stoichiometric reactions suggested that nickel could rapidly coordinate to the alkene motif of substrate 1a, and then initiate next C–H cleavage and alkene insertion (see the Supplementary Information). On the basis of these facts, a plausible mechanism was proposed as below (Fig. 6e): substrate 1a coordinates with AlMe3 and nickel first, and then facilitates Ni-catalyzed C7–H bond cleavage via oxidative addition process. Subsequent irreversible endo-type alkene migratory insertion and reductive elimination generates the Al-coordinated product, which exchanges with another substrate 1a to initiate a next cycle.
Methods
General procedure for Ni-catalyzed C7–H cyclization
To a 15 mL oven dried tube in glove box were added Ni(cod)2 (5.5 mg, 10 mol%), IPr HCl (8.6 mg, 10 mol%), tBuOK (9 mg, 0.08 mmol, 40 mol%), benzoimidazole 1 (0.2 mmol), dry degassed toluene (2.0 mL), and AlMe3 (1.0 M/hexane, 10 mol% or 60 mol% or 200 mol%). The tube was capped, taken outside the glove box, and stirred at 130 °C for 3 h. After that, the mixture was cooled to r.t., quenched with 2 mL of 5% EDTA disodium salt solution, and filtered through a short plug of silica gel, eluting with EtOAc. The filtration was concentrated in vacuo to afford the crude product, which was further purified by flash column chromatography on silica gel (EtOAc/hexanes).
Data availability
The authors declare that the data supporting the findings of this study are available within the article and its Supplementary Information file. For the experimental procedures, data of NMR and HPLC analysis, see Supplementary Methods in Supplementary Information file. The X-ray crystallographic coordinates for structures reported in this study have been deposited at the Cambridge Crystallographic Data Centre (CCDC), under deposition number CCDC 2009572. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via https://www.ccdc.cam.ac.uk/structures/.
References
Fukaya, T. et al. Design, synthesis and structure–activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands. Bioorg. Med. Chem. 21, 1257–1267 (2013).
Kern, C., Meyer, T., Droux, S., Schollmeyer, D. & Miculka, C. Synthesis and pharmacological characterization of β2-adrenergic agonist enantiomers: zilpaterol. J. Med. Chem. 52, 1773–1777 (2009).
Lee, G.-W., Cho, S.-H., Kang, H.-R., Oh, H.-S. & Yang, J.-E. Organic electroluminescent compound and organic electroluminescent device comprising the same. PCT Int. Appl. WO2019143184 (2019).
Zetterberg, F., Leffler, H. & Nilsson, U. Preparation of triazole α-D-galactosides as inhibitors of galectins. PCT Int. Appl. WO2018110930 (2018).
Casazza, U. & Pedro Ponce, G. Improved method for preparing zilpaterol. PCT Int. Appl. WO2015174812 (2015).
Stoessel, P., Joosten, D., Breuning, E. & Kaiser, J.Metal complexes with heterocyclic ligands and their preparation and use in electronic devices. PCT Int. Appl. WO2014008982 (2014).
Toyoda, T. et al. Preparation of isoindole-1,3-dione derivatives as 5-HT1A receptor agonists. PCT Int. Appl. WO2008047839 (2008).
Molander, G. A. Diverse methods for medium ring synthesis. Acc. Chem. Res. 31, 603–609 (1998).
Chattopadhyay, S. K. et al. Formation of medium-ring heterocycles by diene and enyne metathesis. Tetrahedron 63, 3919–3952 (2007).
Clarke, A. K. & Unsworth, W. P. A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion. Chem. Sci. 11, 2876–2881 (2020).
Salaski, E. Synthesis of imidazobenzazepinthiones: a new series of HIV-1 reverse transcriptase inhibitors. Tetrahedron Lett. 36, 1387–1390 (1995).
Krebs, O., Reuter, K., Kuenti, P. & Michlig, C. Process for making a crystalline zilpaterol salt. PCT Int. Appl. WO2010070004 (2010).
Boyle, J., Fenwick, A. E., Gethin, D. M. & Mccusker, C. F. Preparation of imidazo[4,5,1-jk][1]benzazepin-2(1H)-one derivatives as anabolic agents. PCT Int. Appl. WO2008044127 (2008).
Towson, J. C. & Wong, S.-C. An improved process for making zilpaterol. PCT Int. Appl. WO2014095822 (2014).
Heald, R. et al. Preparation of heterocyclic compounds as selective inhibitors of the p110 delta isoform of PI3K for treating inflammation, immune diseases and cancers. U.S. Pat. Appl. Publ. US20120202785 (2012).
Li, R., Xu, X. T. & Ye, M. C. Construction of medium rings via transition metal-catalyzed insertion of π-unsaturated compounds into C—H bonds. Chin. J. Org. Chem. 40, 3196–3202 (2020).
Meyer, A. G. et al. Seven-membered rings. Prog. Heterocycl. Chem. 31, 597–647 (2020).
Aloise, A. D., Layton, M. E. & Shair, M. D. Synthesis of cyclooctenones using intramolecular hydroacylation. J. Am. Chem. Soc. 122, 12610–12611 (2000).
Sato, Y., Oonishi, Y. & Mori, M. A new method for the synthesis of cycloheptenones by RhI-catalyzed intramolecular hydroacylation of 4,6-dienals. Angew. Chem. Int. Ed. 41, 1218–1221 (2002).
Crépin, D., Dawick, J. & Aïssa, C. Combined rhodium-catalyzed carbon-hydrogen activation and β-carbon elimination to access eight-membered rings. Angew. Chem. Int. Ed. 49, 620–623 (2010).
Bendorf, H. D. et al. Chelation-assisted intramolecular hydroacylation: synthesis of medium ring sulfur heterocycles. Tetrahedron Lett. 43, 7031–7034 (2002).
Bendorf, H. D. et al. Amine-directed intramolecular hydroacylation of alkenes and alkynes. Tetrahedron Lett. 53, 1275–1277 (2012).
Shen, Z. M., Khan, H. A. & Dong, V. M. Rhodium-catalyzed carbonyl hydroacylation: an enantioselective approach to lactones. J. Am. Chem. Soc. 130, 2916–2917 (2008).
Shen, Z. M., Dornan, P. K., Khan, H. A., Woo, T. K. & Dong, V. M. Mechanistic insights into the rhodium-catalyzed intramolecular ketone hydroacylation. J. Am. Chem. Soc. 131, 1077–1091 (2009).
Coulter, M. M., Dornan, P. K. & Dong, V. M. Rh-catalyzed intramolecular olefin hydroacylation: enantioselective synthesis of seven- and eight-membered heterocycles. J. Am. Chem. Soc. 131, 6932–6933 (2009).
Khan, H. A., Kou, K. G. M. & Dong, V. M. Nitrogen-directed ketone hydroacylation: enantioselective synthesis of benzoxazecinones. Chem. Sci. 2, 407–410 (2011).
Arnold, J. S., Mwenda, E. T. & Nguyen, H. M. Rhodium-catalyzed sequential allylic amination and olefin hydroacylation reactions: enantioselective synthesis of seven-membered nitrogen heterocycles. Angew. Chem. Int. Ed. 53, 3688–3692 (2014).
Beletskiy, E. V., Sudheer, C. & Douglas, C. J. Cooperative catalysis approach to intramolecular hydroacylation. J. Org. Chem. 77, 5884–5893 (2012).
Shen, D., Zhang, W. B., Li, Z. Y., Shi, S. L. & Xu, Y. J. Nickel/NHC-catalyzed enantioselective cyclization of pyridones and pyrimidones with tethered alkenes. Adv. Synth. Catal. 362, 1125–1130 (2020).
Cai, Y., Ye, X. D., Liu, S. & Shi, S. L. Nickel/NHC-catalyzed asymmetric C-H alkylation of fluoroarenes with alkenes: synthesis of enantioenriched fluorotetralins. Angew. Chem. Int. Ed. 58, 13433–13437 (2019).
Zhang, W. B., Yang, X. T., Ma, J. B., Su, Z. M. & Shi, S. L. Regio- and enantioselective C-H cyclization of pyridines with alkenes enabled by a Nickel/N-heterocyclic carbene catalysis. J. Am. Chem. Soc. 141, 5628–5634 (2019).
Diesel, J., Grosheva, D., Kodama, S. & Cramer, N. A bulky chiral N-heterocyclic carbene nickel catalyst enables enantioselective C-H functionalizations of indoles and pyrroles. Angew. Chem. Int. Ed. 58, 11044–11048 (2019).
Diesel, J., Finogenova, A. M. & Cramer, N. Nickel-catalyzed enantioselective pyridone C-H functionalizations enabled by a bulky N-heterocyclic carbene ligand. J. Am. Chem. Soc. 140, 4489–4493 (2018).
Donets, P. A. & Cramer, N. Ligand-controlled regiodivergent nickel-catalyzed annulation of pyridones. Angew. Chem. Int. Ed. 54, 633–637 (2015).
Saper, N. I. et al. Nickel catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions. Nat. Chem. 12, 276–283 (2020).
Nakao, Y., Kanyiva, K. S. & Hiyama, T. A strategy for C–H activation of pyridines: direct C-2 selective alkenylation of pyridines by nickel/Lewis acid catalysis. J. Am. Chem. Soc. 130, 2448–2449 (2008).
Nakao, Y., Idei, H., Kanyiva, K. S. & Hiyama, T. Hydrocarbamoylation of unsaturated bonds by nickel/Lewis-acid catalysis. J. Am. Chem. Soc. 131, 5070–5071 (2009).
Tsai, C. C. et al. Bimetallic nickel aluminun mediated para-selective alkenylation of pyridine: direct observation of η2,η1 -Pyridine Ni(0)-Al(III) intermediates prior to C-H bond activation. J. Am. Chem. Soc. 132, 11887–11889 (2010).
Lee, W.-C. et al. Nickelcatalysed para-C-H activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes. Chem. Commun. 51, 17104–17107 (2015).
Yu, M.-S., Lee, W.-C., Chen, C.-H., Tsai, F.-Y. & Ong, T.-G. Controlled regiodivergent C–H bond activation of imidazo[1,5-a]pyridine via synergistic cooperation between aluminum and nickel. Org. Lett. 16, 4826–4829 (2014).
Yang, L., Semba, K. & Nakao, Y. para-Selective C–H borylation of (hetero)arenes by cooperative iridium/aluminum catalysis. Angew. Chem., Int. Ed. 56, 4853–4857 (2017).
Liu, Q.-S. et al. Ni–Al bimetallic catalyzed enantioselective cycloaddition of cyclopropyl carboxamide with alkyne. J. Am. Chem. Soc. 139, 18150–18153 (2017).
Wang, Y.-X. et al. Enantioselective Ni–Al bimetallic catalyzed exo-selective C–H cyclization of imidazoles with alkenes. J. Am. Chem. Soc. 140, 5360–5364 (2018).
Chen, H., Wang, Y.-X., Luan, Y.-X. & Ye, M. Enantioselective twofold C–H annulation of formamides and alkynes without built-in chelating groups. Angew. Chem., Int. Ed. 59, 9428–9432 (2020).
Zhang, T., Luan, Y.-X., Zheng, S.-J., Peng, Q. & Ye, M. Chiral aluminum complex controls enantioselective nickel-catalyzed synthesis of indenes: C–CN bond activation. Angew. Chem. Int. Ed. 59, 7439–7443 (2020).
Wang, Y.-X. & Ye, M. Recent advances in Ni–Al bimetallic catalysis for unreactive bond transformation. Sci. China. Chem. 61, 1004–1013 (2018).
Hu, Y. & Wang, C. Bimetallic C―H activation in homogeneous catalysis. Acta Phys. Chim. Sin. 35, 913–922 (2019).
Schramm, Y., Takeuchi, M., Semba, K., Nakao, Y. & Hartwig, J. F. Anti-Markovnikov hydroheteroarylation of unactivated alkenes with indoles, pyrroles, benzofurans, and furans catalyzed by a nickel–N-heterocyclic carbene system. J. Am. Chem. Soc. 137, 12215–12218 (2015).
Yao, W. W., Li, R., Li, J. F., Sun, J. & Ye, M. NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant. Green. Chem. 21, 2240–2244 (2019).
Cai, Y. et al. Copper-catalyzed enantioselective markovnikov protoboration of α-olefins enabled by a buttressed N–heterocyclic carbene ligand. Angew. Chem. Int. Ed. 57, 1376–1380 (2018).
Cai, Y., Zhang, J.-W., Li, F., Liu, J.-M. & Shi, S.-L. Nickel/N-heterocyclic carbene complex-catalyzed enantioselective redox-neutral coupling of benzyl alcohols and alkynes to allylic alcohols. ACS Catal. 9, 1–6 (2019).
Acknowledgements
We thank the National Natural Science Foundation of China (21871145 and 91856104), the Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan (19JCZDJC37900) for financial support for financial support.
Author information
Authors and Affiliations
Contributions
J.-F.L. discovered and developed the reactions. W.-W. X., R.-H. W., Y.L., G.Y. performed part of synthetic experiments. M.Y. conceived, designed the investigations and wrote the manuscript. J.-F.L. wrote the Supplementary Information.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Peer review information Nature Communications thanks Tiow-Gan Ong, Shi-Liang Shi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Li, JF., Xu, WW., Wang, RH. et al. Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles. Nat Commun 12, 3070 (2021). https://doi.org/10.1038/s41467-021-23371-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41467-021-23371-x
This article is cited by
-
Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides
Nature Communications (2022)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
