Fig. 6: Cell-type-specific prediction of variation affecting TF occupancy. | Nature Communications

Fig. 6: Cell-type-specific prediction of variation affecting TF occupancy.

From: Tissue context determines the penetrance of regulatory DNA variation

Fig. 6

a. CATO2 strategy for cell-type-specific scoring of regulatory variation. b. The number of mouse cell types used for each TF model; all TF models included human data. c. The number of unique TF clusters with non-zero coefficients in aggregate and cell-type-specific CATO2 scores. TFs shared with the aggregate model are highlighted in blue. d The area under precision-recall curves (full curves are shown in Supplementary Fig. 7) showing performance to predict imbalanced polymorphism on SNVs tested for imbalance in individual cell types.

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