Fig. 2: OVs are effective adjuvants for immune boosting. | Nature Communications

Fig. 2: OVs are effective adjuvants for immune boosting.

From: Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination

Fig. 2

a Treatment schedule used in this study. b IFNγ ELISPOT analysis of splenocytes from mice primed with Ad-DCT and boosted with either VV, VSV or MRB co-administered with DCT peptide (from left to right; n = 2, 3, 5, 5 and 5); c primed with Ad-DCT and boosted with MRB-DCT or MRB co-administered with DCT peptide (MRB + DCT) (from left to right; n = 4, 4, 5 and 5); d primed with Ad-Ova and boosted with MRB-Ova, MRB co-administered with Ova peptide (MRB + Ova) or Ova peptide only (from left to right; n = 2, 3, 4, 5 and 5). e Flow cytometry analysis of splenocytes from the same experiment as in (d) (from left to right; n = 2, 3, 4, 5 and 5) or (f) from mice primed with Ad-E6/E7 and boosted with MRB-E6/E7 or MRB co-administered with E6/E7 peptides (from left to right; n = 5, 5, 14 and 5). Unless indicated otherwise, the statistical analyses refer to the comparison between the corresponding ex-vivo “No restim” and “restim” conditions. NS: p > 0.05, *: p < 0.05, **: p < 0.01, ***: p < 0.001 (unpaired two-tailed t-test). Source data are provided as a Source Data file. Exact p values can be found in the Source Data.

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