Fig. 6: Heterogeneous patterns of genetic and epigenetic evolution in AML patients treated with IDHi. | Nature Communications

Fig. 6: Heterogeneous patterns of genetic and epigenetic evolution in AML patients treated with IDHi.

From: Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

Fig. 6

AE Multidimensional longitudinal plot of mutation VAFs, bone marrow (BM) blast counts, absolute neutrophil count (ANC), hemoglobin (HGB) counts, platelet (PLT) counts, 2HG level, and DNA methylation level in UPN1825001 (A), UPN2463247 (B), UPN2297625 (C), UPN2620771 (D), and UPN2370759 (E). Line plots show mutation VAFs, ANC/HGB/PLT counts, and 2HG level. Blue shades represent BM blast counts. Violin plots show the methylation distribution. Violin plot shows the minimum, first quartile (Q1), median, third quartile (Q3), and maximum. Source data are provided as Source data files.

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