Fig. 5: Selection of resistant mutations accompanies relapse after IDHi. | Nature Communications

Fig. 5: Selection of resistant mutations accompanies relapse after IDHi.

From: Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

Fig. 5

A Longitudinal mutation landscape plot showing mutation acquisitions in 16 out of the 18 tested relapsed cases. Each column represents an individual case with differentially shaped triangles representing mutation status in either baseline or relapse. B Bar plot showing percentage of tested relapsed cases with acquired mutations in various genes and pathways. C The longitudinal trajectory of mutation VAFs, bone marrow (BM) blast counts, absolute neutrophil count (ANC), hemoglobin (HGB) counts, and platelet (PLT) counts in UPN2394529 (C). Line plots show mutation VAFs and ANC/HGB/PLT counts. Blue shades represent BM blast counts. D Single-cell landscape of selected mutations in UPN2394529. Each column represents one individual cell. A total of 1000 cells scale bar is shown on the top left. E GSEA comparing gene expression data from RNA sequencing between baseline and relapse samples showing significant enrichment of E2F targets, TNF alpha signaling via NF-kappa B, and G2M checkpoint genes, in relapse samples. Source data are provided as Source data files.

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