A List of top driver transcription factors (TF) and signaling genes (SIG) identified by NetBID2 analysis by comparing gene expression profiles between cluster 1 and cluster 2 (P < 0.01 was used as the significance cutoff). Drivers identified for cluster 1 and cluster 2 are colored with red and blue, respectively. B Heatmap of NetBID-based activity of top drivers in cluster 2. Samples in cluster 1 (CL1) are labeled as red, while cluster 2 (CL2) are labeled as blue. C LSC17 score was calculated for each baseline sample and compared between patients achieving CR (N = 9) vs. not (N = 30) and OR (N = 16) vs. not (N = 23). *P < 0.05 (P = 0.011 for CR vs. non-CR; P = 0.037 for OR vs. non-OR). Box plot shows the minimum, first quartile (Q1), median, third quartile (Q3), and maximum. D, E Receiver operating curve (ROC) for predicting CR or OR with LSC17 score, RUNX1 mutation status, RAS-RTK mutation status, and ELN cytogenetic risk classification. Source data are provided as Source data files.