Fig. 7: T cell-related genes differentially expressed in peptide-stimulated PBMC from Pandemrix-associated NT1 patients (RNA-seq). | Nature Communications

Fig. 7: T cell-related genes differentially expressed in peptide-stimulated PBMC from Pandemrix-associated NT1 patients (RNA-seq).

From: Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Fig. 7

Dot plots demonstrating the expression levels (normalized read counts) of nine T cell-related genes showing significant differences in expression (**p < 0.01) between NT1 patients and controls either after stimulation with NA175–189 or POMT1675-689 peptides (compare Fig. 6). Differentially expressed genes were identified using edgeR, based on a test analogous to Fisher’s exact test. The paired method was used for comparisons, calculating 2-sided p-values and adjusting for multiple testing using BH correction. The lines indicate paired data of two strong responders, NT1 patients P003 and P015.

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