Fig. 5: Autoreactive T-cells in Pandemrix-associated NT1. | Nature Communications

Fig. 5: Autoreactive T-cells in Pandemrix-associated NT1.

From: Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Fig. 5

a, b PBMC from pediatric Pandemrix-associated NT1 patients (NT1) or pediatric Pandemrix-vaccinated healthy controls (C) were stimulated in culture with overlapping 15-mer peptides derived from human protein-O-mannosyltransferase 1 (POMT1) or syntrophin gamma-1 (SNTG1), as indicated. The secretion of IFN-γ was measured by FMIA (protein). HLA-DQB1*0602 homozygous NT1 patients are marked with red dots. Results are expressed as the ratio between cytokine concentrations measured in peptide-stimulated and negative control samples (stimulation index). Statistical comparisons between groups were performed, using Kruskal–Wallis and Dunn’s multiple comparisons tests.

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